PGC-1 Coactivators: Shepherding the Mitochondrial Biogenesis of Tumors

Chi Luo, Hans R. Widlund, Pere Puigserver

Research output: Contribution to journalReview articlepeer-review

Abstract

As coordinators of energy demands and nutritional supplies, the peroxisome proliferator-activated receptor γ (PPARγ) coactivator 1 (PGC-1) family of transcriptional coactivators regulates mitochondrial biogenesis to control the cellular bioenergetic state. Aside from maintaining normal and adapted cell physiology, recent studies indicate that PGC-1 coactivators also serve important functions in cancer cells. In fact, by balancing mitochondrial energy production with demands for cell proliferation, these factors are involved in almost every step of tumorigenesis. In this review, we discuss the interplay between PGC-1 coactivators and cancer pathogenesis, including tumor initiation, metastatic spread, and response to treatment. Given their involvement in the functional biology of cancers, identification of regulatory targets that influence PGC-1 expression and activity may reveal novel strategies suitable for mono- or combinatorial cancer therapies.

Original languageEnglish (US)
Pages (from-to)619-631
Number of pages13
JournalTrends in Cancer
Volume2
Issue number10
DOIs
StatePublished - Oct 1 2016
Externally publishedYes

Keywords

  • cancer metabolism
  • mitochondrial biogenesis
  • transcriptional coactivators

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'PGC-1 Coactivators: Shepherding the Mitochondrial Biogenesis of Tumors'. Together they form a unique fingerprint.

Cite this