PEX11 promotes peroxisome division independently of peroxisome metabolism

Xiaoling Li, Stephen J. Gould

Research output: Contribution to journalArticle

Abstract

The PEX11 peroxisomal membrane proteins are the only factors known to promote peroxisome division in multiple species. It has been proposed that PEX11 proteins have a direct role in peroxisomal fatty acid oxidation, and that they only affect peroxisome abundance indirectly. Here we show that PEX11 proteins are unique in their ability to promote peroxisome division, and that PEX11 overexpression promotes peroxisome division in the absence of peroxisomal metabolic activity. We also observed that mouse cells lacking PEX11β display reduced peroxisome abundance, even in the absence of peroxisomal metabolic substrates, and that PEX11β-/- mice are partially deficient in two distinct peroxisomal metabolic pathways, ether lipid synthesis and very long chain fatty acid oxidation. Based on these and other observations, we propose that PEX11 proteins act directly in peroxisome division, and that their loss has indirect effects on peroxisome metabolism.

Original languageEnglish (US)
Pages (from-to)643-651
Number of pages9
JournalJournal of Cell Biology
Volume156
Issue number4
DOIs
StatePublished - Feb 18 2002

Keywords

  • Fatty acid oxidation
  • Organelle division
  • Peroxisomal membrane protein
  • Peroxisome biogenesis
  • Zellweger syndrome

ASJC Scopus subject areas

  • Cell Biology

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