PET studies of domoic acid poisoning in humans: excitotoxic destruction of brain glutamatergic pathways, revealed in measurements of glucose metabolism by positron emission tomography.

A. Gjedde, A. C. Evans

Research output: Contribution to journalArticle

Abstract

We used positron emission tomography to measure hippocampal and medial temporal lobe metabolism in brains of patients intoxicated by domoic acid from Prince Edward Island mussels. This analog of kainic acid specifically excites certain neurons in the hippocampus, and the study revealed a severe reduction of glucose metabolism in this part of the brain which paralleled the absence of long-, medium-, or short-term memory in these patients.

Original languageEnglish (US)
Pages (from-to)105-109
Number of pages5
JournalCanada diseases weekly report
Volume16 Suppl 1E
StatePublished - Sep 1990
Externally publishedYes

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Positron-Emission Tomography
Poisoning
Prince Edward Island
Glucose
Kainic Acid
Bivalvia
Brain
Temporal Lobe
Short-Term Memory
Hippocampus
Neurons
domoic acid

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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abstract = "We used positron emission tomography to measure hippocampal and medial temporal lobe metabolism in brains of patients intoxicated by domoic acid from Prince Edward Island mussels. This analog of kainic acid specifically excites certain neurons in the hippocampus, and the study revealed a severe reduction of glucose metabolism in this part of the brain which paralleled the absence of long-, medium-, or short-term memory in these patients.",
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