PET-measured responses of MBF to cold pressor testing correlate with indices of coronary vasomotion on quantitative coronary angiography

Thomas H. Schindler, Egbert U. Nitzsche, Manfred Olschewski, Ingo Brink, Michael Mix, John Prior, Alvaro Facta, Massayuki Inubushi, Hanjoerg Just, Heinrich R. Schelbert

Research output: Contribution to journalArticle

Abstract

The aims of this study were to determine whether responses in myocardial blood flow (MBF) to the cold pressor testing (CPT) method noninvasively with PET correlate with an established and validated index of flow-dependent coronary vasomotion on quantitative angiography. Methods: Fifty-six patients (57 ± 6 y; 16 with hypertension, 10 with hypercholesterolemia, 8 smokers, and 22 without coronary risk factors) with normal coronary angiograms were studied. Biplanar end-diastolic images of a selected proximal segment of the left anterior descending artery (LAD) (n = 27) or left circumflex artery (LCx) (n = 29) were evaluated with quantitative coronary angiography in order to determine the CPT-induced changes of epicardial luminal area (LA, mm2). Within 20 d of coronary angiography, MBF in the LAD, LCx, and right coronary artery territory was measured with 13N-ammonia and PET at baseline and during CPT. Results: CPT induced on both study days comparable percent changes in the rate x pressure product (%ΔRPP, 37% ± 13% and 40% ± 17%; P = not significant [NS]). For the entire study group, the epicardial LA decreased from 5.07 ± 1.02 to 4.88 ± 1.04 mm2 (ΔLA, - 0.20 ± 0.89 mm2) or by -2.19% ± 17%, while MBF in the corresponding epicardial vessel segment increased from 0.76 ± 0.16 to 1.03 ± 0.33 mL·min-1·g -1 (ΔMBF, 0.27 ± 0.25 mL·min -1·g-1) or 36% ± 31% (P <0.0001). However, in normal controls without coronary risk factors (n = 22), the epicardial LA increased from 5.01 ± 1.07 to 5.88 ± 0.89 mm 2 (19.06% ± 8.9%) and MBF increased from 0.77 ± 0.16 to 1.34 ± 0.34 mL·min-1·g-1 (74.08% ± 23.5%) during CPT, whereas patients with coronary risk factors (n = 34) revealed a decrease of epicardial LA from 5.13 ± 1.48 to 4.24 ± 1.12 mm2 (-15.94% ± 12.2%) and a diminished MBF increase (from 0.76 ± 0.20 to 0.83 ± 0.25 mL·min -1·g-1 or 10.91% ± 19.8%) as compared with controls (P <0.0001, respectively), despite comparable changes in the RPP (P = NS). In addition, there was a significant correlation (r = 0.87; P ≤ 0.0001) between CPT-related percent changes in LA on quantitative angiography and in MBF as measured with PET. Conclusion: The observed close correlation between an angiographically established parameter of flow-dependent and, most likely, endothelium-mediated coronary vasomotion and PET-measured MBF further supports the validity and value of MBF responses to CPT as a noninvasively available index of coronary circulatory function.

Original languageEnglish (US)
Pages (from-to)419-428
Number of pages10
JournalJournal of Nuclear Medicine
Volume45
Issue number3
StatePublished - Mar 1 2004
Externally publishedYes

Fingerprint

Coronary Angiography
Arteries
Angiography
Hypercholesterolemia
Ammonia
Endothelium
Coronary Vessels
Hypertension
Pressure

Keywords

  • Blood flow
  • Cold pressor test
  • Endothelium, PET
  • Vasoconstriction

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Schindler, T. H., Nitzsche, E. U., Olschewski, M., Brink, I., Mix, M., Prior, J., ... Schelbert, H. R. (2004). PET-measured responses of MBF to cold pressor testing correlate with indices of coronary vasomotion on quantitative coronary angiography. Journal of Nuclear Medicine, 45(3), 419-428.

PET-measured responses of MBF to cold pressor testing correlate with indices of coronary vasomotion on quantitative coronary angiography. / Schindler, Thomas H.; Nitzsche, Egbert U.; Olschewski, Manfred; Brink, Ingo; Mix, Michael; Prior, John; Facta, Alvaro; Inubushi, Massayuki; Just, Hanjoerg; Schelbert, Heinrich R.

In: Journal of Nuclear Medicine, Vol. 45, No. 3, 01.03.2004, p. 419-428.

Research output: Contribution to journalArticle

Schindler, TH, Nitzsche, EU, Olschewski, M, Brink, I, Mix, M, Prior, J, Facta, A, Inubushi, M, Just, H & Schelbert, HR 2004, 'PET-measured responses of MBF to cold pressor testing correlate with indices of coronary vasomotion on quantitative coronary angiography', Journal of Nuclear Medicine, vol. 45, no. 3, pp. 419-428.
Schindler, Thomas H. ; Nitzsche, Egbert U. ; Olschewski, Manfred ; Brink, Ingo ; Mix, Michael ; Prior, John ; Facta, Alvaro ; Inubushi, Massayuki ; Just, Hanjoerg ; Schelbert, Heinrich R. / PET-measured responses of MBF to cold pressor testing correlate with indices of coronary vasomotion on quantitative coronary angiography. In: Journal of Nuclear Medicine. 2004 ; Vol. 45, No. 3. pp. 419-428.
@article{5c2d8b38973846db87151aa426301fc0,
title = "PET-measured responses of MBF to cold pressor testing correlate with indices of coronary vasomotion on quantitative coronary angiography",
abstract = "The aims of this study were to determine whether responses in myocardial blood flow (MBF) to the cold pressor testing (CPT) method noninvasively with PET correlate with an established and validated index of flow-dependent coronary vasomotion on quantitative angiography. Methods: Fifty-six patients (57 ± 6 y; 16 with hypertension, 10 with hypercholesterolemia, 8 smokers, and 22 without coronary risk factors) with normal coronary angiograms were studied. Biplanar end-diastolic images of a selected proximal segment of the left anterior descending artery (LAD) (n = 27) or left circumflex artery (LCx) (n = 29) were evaluated with quantitative coronary angiography in order to determine the CPT-induced changes of epicardial luminal area (LA, mm2). Within 20 d of coronary angiography, MBF in the LAD, LCx, and right coronary artery territory was measured with 13N-ammonia and PET at baseline and during CPT. Results: CPT induced on both study days comparable percent changes in the rate x pressure product ({\%}ΔRPP, 37{\%} ± 13{\%} and 40{\%} ± 17{\%}; P = not significant [NS]). For the entire study group, the epicardial LA decreased from 5.07 ± 1.02 to 4.88 ± 1.04 mm2 (ΔLA, - 0.20 ± 0.89 mm2) or by -2.19{\%} ± 17{\%}, while MBF in the corresponding epicardial vessel segment increased from 0.76 ± 0.16 to 1.03 ± 0.33 mL·min-1·g -1 (ΔMBF, 0.27 ± 0.25 mL·min -1·g-1) or 36{\%} ± 31{\%} (P <0.0001). However, in normal controls without coronary risk factors (n = 22), the epicardial LA increased from 5.01 ± 1.07 to 5.88 ± 0.89 mm 2 (19.06{\%} ± 8.9{\%}) and MBF increased from 0.77 ± 0.16 to 1.34 ± 0.34 mL·min-1·g-1 (74.08{\%} ± 23.5{\%}) during CPT, whereas patients with coronary risk factors (n = 34) revealed a decrease of epicardial LA from 5.13 ± 1.48 to 4.24 ± 1.12 mm2 (-15.94{\%} ± 12.2{\%}) and a diminished MBF increase (from 0.76 ± 0.20 to 0.83 ± 0.25 mL·min -1·g-1 or 10.91{\%} ± 19.8{\%}) as compared with controls (P <0.0001, respectively), despite comparable changes in the RPP (P = NS). In addition, there was a significant correlation (r = 0.87; P ≤ 0.0001) between CPT-related percent changes in LA on quantitative angiography and in MBF as measured with PET. Conclusion: The observed close correlation between an angiographically established parameter of flow-dependent and, most likely, endothelium-mediated coronary vasomotion and PET-measured MBF further supports the validity and value of MBF responses to CPT as a noninvasively available index of coronary circulatory function.",
keywords = "Blood flow, Cold pressor test, Endothelium, PET, Vasoconstriction",
author = "Schindler, {Thomas H.} and Nitzsche, {Egbert U.} and Manfred Olschewski and Ingo Brink and Michael Mix and John Prior and Alvaro Facta and Massayuki Inubushi and Hanjoerg Just and Schelbert, {Heinrich R.}",
year = "2004",
month = "3",
day = "1",
language = "English (US)",
volume = "45",
pages = "419--428",
journal = "Journal of Nuclear Medicine",
issn = "0161-5505",
publisher = "Society of Nuclear Medicine Inc.",
number = "3",

}

TY - JOUR

T1 - PET-measured responses of MBF to cold pressor testing correlate with indices of coronary vasomotion on quantitative coronary angiography

AU - Schindler, Thomas H.

AU - Nitzsche, Egbert U.

AU - Olschewski, Manfred

AU - Brink, Ingo

AU - Mix, Michael

AU - Prior, John

AU - Facta, Alvaro

AU - Inubushi, Massayuki

AU - Just, Hanjoerg

AU - Schelbert, Heinrich R.

PY - 2004/3/1

Y1 - 2004/3/1

N2 - The aims of this study were to determine whether responses in myocardial blood flow (MBF) to the cold pressor testing (CPT) method noninvasively with PET correlate with an established and validated index of flow-dependent coronary vasomotion on quantitative angiography. Methods: Fifty-six patients (57 ± 6 y; 16 with hypertension, 10 with hypercholesterolemia, 8 smokers, and 22 without coronary risk factors) with normal coronary angiograms were studied. Biplanar end-diastolic images of a selected proximal segment of the left anterior descending artery (LAD) (n = 27) or left circumflex artery (LCx) (n = 29) were evaluated with quantitative coronary angiography in order to determine the CPT-induced changes of epicardial luminal area (LA, mm2). Within 20 d of coronary angiography, MBF in the LAD, LCx, and right coronary artery territory was measured with 13N-ammonia and PET at baseline and during CPT. Results: CPT induced on both study days comparable percent changes in the rate x pressure product (%ΔRPP, 37% ± 13% and 40% ± 17%; P = not significant [NS]). For the entire study group, the epicardial LA decreased from 5.07 ± 1.02 to 4.88 ± 1.04 mm2 (ΔLA, - 0.20 ± 0.89 mm2) or by -2.19% ± 17%, while MBF in the corresponding epicardial vessel segment increased from 0.76 ± 0.16 to 1.03 ± 0.33 mL·min-1·g -1 (ΔMBF, 0.27 ± 0.25 mL·min -1·g-1) or 36% ± 31% (P <0.0001). However, in normal controls without coronary risk factors (n = 22), the epicardial LA increased from 5.01 ± 1.07 to 5.88 ± 0.89 mm 2 (19.06% ± 8.9%) and MBF increased from 0.77 ± 0.16 to 1.34 ± 0.34 mL·min-1·g-1 (74.08% ± 23.5%) during CPT, whereas patients with coronary risk factors (n = 34) revealed a decrease of epicardial LA from 5.13 ± 1.48 to 4.24 ± 1.12 mm2 (-15.94% ± 12.2%) and a diminished MBF increase (from 0.76 ± 0.20 to 0.83 ± 0.25 mL·min -1·g-1 or 10.91% ± 19.8%) as compared with controls (P <0.0001, respectively), despite comparable changes in the RPP (P = NS). In addition, there was a significant correlation (r = 0.87; P ≤ 0.0001) between CPT-related percent changes in LA on quantitative angiography and in MBF as measured with PET. Conclusion: The observed close correlation between an angiographically established parameter of flow-dependent and, most likely, endothelium-mediated coronary vasomotion and PET-measured MBF further supports the validity and value of MBF responses to CPT as a noninvasively available index of coronary circulatory function.

AB - The aims of this study were to determine whether responses in myocardial blood flow (MBF) to the cold pressor testing (CPT) method noninvasively with PET correlate with an established and validated index of flow-dependent coronary vasomotion on quantitative angiography. Methods: Fifty-six patients (57 ± 6 y; 16 with hypertension, 10 with hypercholesterolemia, 8 smokers, and 22 without coronary risk factors) with normal coronary angiograms were studied. Biplanar end-diastolic images of a selected proximal segment of the left anterior descending artery (LAD) (n = 27) or left circumflex artery (LCx) (n = 29) were evaluated with quantitative coronary angiography in order to determine the CPT-induced changes of epicardial luminal area (LA, mm2). Within 20 d of coronary angiography, MBF in the LAD, LCx, and right coronary artery territory was measured with 13N-ammonia and PET at baseline and during CPT. Results: CPT induced on both study days comparable percent changes in the rate x pressure product (%ΔRPP, 37% ± 13% and 40% ± 17%; P = not significant [NS]). For the entire study group, the epicardial LA decreased from 5.07 ± 1.02 to 4.88 ± 1.04 mm2 (ΔLA, - 0.20 ± 0.89 mm2) or by -2.19% ± 17%, while MBF in the corresponding epicardial vessel segment increased from 0.76 ± 0.16 to 1.03 ± 0.33 mL·min-1·g -1 (ΔMBF, 0.27 ± 0.25 mL·min -1·g-1) or 36% ± 31% (P <0.0001). However, in normal controls without coronary risk factors (n = 22), the epicardial LA increased from 5.01 ± 1.07 to 5.88 ± 0.89 mm 2 (19.06% ± 8.9%) and MBF increased from 0.77 ± 0.16 to 1.34 ± 0.34 mL·min-1·g-1 (74.08% ± 23.5%) during CPT, whereas patients with coronary risk factors (n = 34) revealed a decrease of epicardial LA from 5.13 ± 1.48 to 4.24 ± 1.12 mm2 (-15.94% ± 12.2%) and a diminished MBF increase (from 0.76 ± 0.20 to 0.83 ± 0.25 mL·min -1·g-1 or 10.91% ± 19.8%) as compared with controls (P <0.0001, respectively), despite comparable changes in the RPP (P = NS). In addition, there was a significant correlation (r = 0.87; P ≤ 0.0001) between CPT-related percent changes in LA on quantitative angiography and in MBF as measured with PET. Conclusion: The observed close correlation between an angiographically established parameter of flow-dependent and, most likely, endothelium-mediated coronary vasomotion and PET-measured MBF further supports the validity and value of MBF responses to CPT as a noninvasively available index of coronary circulatory function.

KW - Blood flow

KW - Cold pressor test

KW - Endothelium, PET

KW - Vasoconstriction

UR - http://www.scopus.com/inward/record.url?scp=2342569644&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2342569644&partnerID=8YFLogxK

M3 - Article

VL - 45

SP - 419

EP - 428

JO - Journal of Nuclear Medicine

JF - Journal of Nuclear Medicine

SN - 0161-5505

IS - 3

ER -