PET imaging with multimodal upconversion nanoparticles

Juan Gallo, Israt S. Alam, Jiefu Jin, Yan Juan Gu, Eric O. Aboagye, Wing Tak Wong, Nicholas J. Long

Research output: Contribution to journalArticle

Abstract

A series of new upconversion nanoparticles have been functionalised with tumour-targeting molecules and metal chelates, prepared following standard peptidic and thiol chemistry. The targeting strategy has been delivered via the αvβ3 integrin, which is a heterodimeric cell surface receptor that is up-regulated in a variety of cancers, such as melanoma and breast cancer. The well-known DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10- tetraacetic acid) motif allows coordination to the radionuclide 68Ga. Radiolabelling experiments were optimised under relatively mild conditions, and are rare amongst nanoparticulate materials. In vivo application of these probes in mouse tumour models revealed their potential as specific cancer contrast agents for PET imaging. This journal is

Original languageEnglish (US)
Pages (from-to)5535-5545
Number of pages11
JournalDalton Transactions
Volume43
Issue number14
DOIs
StatePublished - Apr 14 2014
Externally publishedYes

ASJC Scopus subject areas

  • Inorganic Chemistry

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  • Cite this

    Gallo, J., Alam, I. S., Jin, J., Gu, Y. J., Aboagye, E. O., Wong, W. T., & Long, N. J. (2014). PET imaging with multimodal upconversion nanoparticles. Dalton Transactions, 43(14), 5535-5545. https://doi.org/10.1039/c3dt53095g