PET imaging of endocannabinoid system

Andrew Horti, Vanessa Raymont, Garth E. Terry

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The endocannabinoid system consists of cannabinoid receptors (which mediate the actions of cannabis), their endogenous ligands (endocannabinoids), and the enzymes and proteins associated with their regulation. In brain, the endocannabinoid system functions to modulate the release of other neurotransmitters via the subtype 1 (CB1) receptor. Abnormalities of CB1 receptor expression or endocannabinoid transmission have been associated with several neuropsychiatric diseases. Subtype 2 (CB2) receptors are found primarily on immune and neuroimmune cells and are overexpressed in states of inflammation and neuroinflammation. Both receptors are of particular interest for biomarker development and therapeutic targets. Growing evidence supports the regulation of endocannabinoids as involved in neuropsychiatric and neuroinflammatory diseases. However, the function of endocannabinoid system components in vivo remains difficult to assess. Therefore, the use of functional imaging techniques, such as positron emission tomography (PET), may be particularly useful in the assessment and quantification of the endocannabinoid system. This chapter will cover the current understanding of functional imaging that directly targets the endocannabinoid system.

Original languageEnglish (US)
Title of host publicationPET and SPECT of Neurobiological Systems
PublisherSpringer Berlin Heidelberg
Pages249-319
Number of pages71
ISBN (Print)9783642420146, 9783642420139
DOIs
StatePublished - Jan 1 2014

Fingerprint

Endocannabinoids
Positron-Emission Tomography
Cannabinoid Receptor CB1
Cannabinoid Receptor CB2
Cannabinoid Receptors
Cannabis
Neurotransmitter Agents
Biomarkers
Ligands
Inflammation
Brain
Enzymes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Horti, A., Raymont, V., & Terry, G. E. (2014). PET imaging of endocannabinoid system. In PET and SPECT of Neurobiological Systems (pp. 249-319). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-642-42014-6_11

PET imaging of endocannabinoid system. / Horti, Andrew; Raymont, Vanessa; Terry, Garth E.

PET and SPECT of Neurobiological Systems. Springer Berlin Heidelberg, 2014. p. 249-319.

Research output: Chapter in Book/Report/Conference proceedingChapter

Horti, A, Raymont, V & Terry, GE 2014, PET imaging of endocannabinoid system. in PET and SPECT of Neurobiological Systems. Springer Berlin Heidelberg, pp. 249-319. https://doi.org/10.1007/978-3-642-42014-6_11
Horti A, Raymont V, Terry GE. PET imaging of endocannabinoid system. In PET and SPECT of Neurobiological Systems. Springer Berlin Heidelberg. 2014. p. 249-319 https://doi.org/10.1007/978-3-642-42014-6_11
Horti, Andrew ; Raymont, Vanessa ; Terry, Garth E. / PET imaging of endocannabinoid system. PET and SPECT of Neurobiological Systems. Springer Berlin Heidelberg, 2014. pp. 249-319
@inbook{e6957b161f674f4789f69dc922737995,
title = "PET imaging of endocannabinoid system",
abstract = "The endocannabinoid system consists of cannabinoid receptors (which mediate the actions of cannabis), their endogenous ligands (endocannabinoids), and the enzymes and proteins associated with their regulation. In brain, the endocannabinoid system functions to modulate the release of other neurotransmitters via the subtype 1 (CB1) receptor. Abnormalities of CB1 receptor expression or endocannabinoid transmission have been associated with several neuropsychiatric diseases. Subtype 2 (CB2) receptors are found primarily on immune and neuroimmune cells and are overexpressed in states of inflammation and neuroinflammation. Both receptors are of particular interest for biomarker development and therapeutic targets. Growing evidence supports the regulation of endocannabinoids as involved in neuropsychiatric and neuroinflammatory diseases. However, the function of endocannabinoid system components in vivo remains difficult to assess. Therefore, the use of functional imaging techniques, such as positron emission tomography (PET), may be particularly useful in the assessment and quantification of the endocannabinoid system. This chapter will cover the current understanding of functional imaging that directly targets the endocannabinoid system.",
author = "Andrew Horti and Vanessa Raymont and Terry, {Garth E.}",
year = "2014",
month = "1",
day = "1",
doi = "10.1007/978-3-642-42014-6_11",
language = "English (US)",
isbn = "9783642420146",
pages = "249--319",
booktitle = "PET and SPECT of Neurobiological Systems",
publisher = "Springer Berlin Heidelberg",

}

TY - CHAP

T1 - PET imaging of endocannabinoid system

AU - Horti, Andrew

AU - Raymont, Vanessa

AU - Terry, Garth E.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - The endocannabinoid system consists of cannabinoid receptors (which mediate the actions of cannabis), their endogenous ligands (endocannabinoids), and the enzymes and proteins associated with their regulation. In brain, the endocannabinoid system functions to modulate the release of other neurotransmitters via the subtype 1 (CB1) receptor. Abnormalities of CB1 receptor expression or endocannabinoid transmission have been associated with several neuropsychiatric diseases. Subtype 2 (CB2) receptors are found primarily on immune and neuroimmune cells and are overexpressed in states of inflammation and neuroinflammation. Both receptors are of particular interest for biomarker development and therapeutic targets. Growing evidence supports the regulation of endocannabinoids as involved in neuropsychiatric and neuroinflammatory diseases. However, the function of endocannabinoid system components in vivo remains difficult to assess. Therefore, the use of functional imaging techniques, such as positron emission tomography (PET), may be particularly useful in the assessment and quantification of the endocannabinoid system. This chapter will cover the current understanding of functional imaging that directly targets the endocannabinoid system.

AB - The endocannabinoid system consists of cannabinoid receptors (which mediate the actions of cannabis), their endogenous ligands (endocannabinoids), and the enzymes and proteins associated with their regulation. In brain, the endocannabinoid system functions to modulate the release of other neurotransmitters via the subtype 1 (CB1) receptor. Abnormalities of CB1 receptor expression or endocannabinoid transmission have been associated with several neuropsychiatric diseases. Subtype 2 (CB2) receptors are found primarily on immune and neuroimmune cells and are overexpressed in states of inflammation and neuroinflammation. Both receptors are of particular interest for biomarker development and therapeutic targets. Growing evidence supports the regulation of endocannabinoids as involved in neuropsychiatric and neuroinflammatory diseases. However, the function of endocannabinoid system components in vivo remains difficult to assess. Therefore, the use of functional imaging techniques, such as positron emission tomography (PET), may be particularly useful in the assessment and quantification of the endocannabinoid system. This chapter will cover the current understanding of functional imaging that directly targets the endocannabinoid system.

UR - http://www.scopus.com/inward/record.url?scp=84943355263&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84943355263&partnerID=8YFLogxK

U2 - 10.1007/978-3-642-42014-6_11

DO - 10.1007/978-3-642-42014-6_11

M3 - Chapter

AN - SCOPUS:84943355263

SN - 9783642420146

SN - 9783642420139

SP - 249

EP - 319

BT - PET and SPECT of Neurobiological Systems

PB - Springer Berlin Heidelberg

ER -