PET-guided biopsy with needle navigation facilitates diagnosis of angiosarcoma in neurofibromatosis type 1

Yilun Koethe, Brigitte C. Widemann, Fouad Hajjar, Bradford J. Wood, Aradhana M. Venkatesan

Research output: Contribution to journalArticle


Malignant degeneration frequently arises from preexisting plexiform neurofibroma in patients with neurofibromatosis type 1 (NF1). Image guided biopsy for diagnostic purposes, such as with CT guidance, can be technically challenging in these patients, as CT cannot distinguish malignant from benign areas within the same tumor. Navigation with multi-modality (PET, CT, and ultrasound) image fusion facilitated the successful biopsy and diagnosis of angiosarcoma arising from a pelvic neurofibroma in a patient with NF1. Successful targeting assisted treatment selection in this case. This novel navigation technique may facilitate the otherwise difficult diagnosis of malignancy in patients with NF1. Pediatr Blood Cancer 2013;60:E166-E169.

Original languageEnglish (US)
Pages (from-to)E166-E169
JournalPediatric Blood and Cancer
Issue number12
StatePublished - Dec 1 2013



  • Image guided biopsy
  • Malignant peripheral neural sheath tumor
  • Neurofibromatosis type 1
  • Plexiform neurofibroma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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