Pet-fdg test-re test reliability during a visual discrimination task in schizophrenia

Henry H. Holcomb, Nicola G. Cascella, Deborah R. Medoff, Edward A. Gastineau, Harry Loats, Gunvant K. Thaker, Robert R. Conley, Robert F Dannals, Henry N. Wagner, Carol A. Tamminga

Research output: Contribution to journalArticle

Abstract

Objective: Reliability of assessment is important in any kind of neuropsychiatric study, but is particularly pivotal in schizophrenia research where symptom instability is common. Materials and Methods: Two fluorodeoxyglucose PET scans, 1 week apart, were carried out in schizophrenic patients while they were performing a simple visual discrimination task. Subject and scan conditions were held constant. Regional metabolic rates of glucose utilization were calculated as absolute and scaled; they were compared using correlational statistics. Results: Average differences between scans were 5-9% for the parietal and occipital cortices, but 1-3% for other cortical areas, differences comparable with reported variances in normal controls. Conclusion: These results suggest that test-retest variance in metabolic im-aging in schizophrenia is relatively low and that task performance increases metabolic stability in brain areas unrelated to task performance.

Original languageEnglish (US)
Pages (from-to)704-709
Number of pages6
JournalJournal of Computer Assisted Tomography
Volume17
Issue number5
StatePublished - 1993

Fingerprint

Pets
Task Performance and Analysis
Schizophrenia
Occipital Lobe
Parietal Lobe
Positron-Emission Tomography
Glucose
Brain
Research

Keywords

  • Emission computed tomography
  • Fluorodeoxyglucose (FDG)
  • Glucose
  • Metabolism
  • Schizophrenia

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Holcomb, H. H., Cascella, N. G., Medoff, D. R., Gastineau, E. A., Loats, H., Thaker, G. K., ... Tamminga, C. A. (1993). Pet-fdg test-re test reliability during a visual discrimination task in schizophrenia. Journal of Computer Assisted Tomography, 17(5), 704-709.

Pet-fdg test-re test reliability during a visual discrimination task in schizophrenia. / Holcomb, Henry H.; Cascella, Nicola G.; Medoff, Deborah R.; Gastineau, Edward A.; Loats, Harry; Thaker, Gunvant K.; Conley, Robert R.; Dannals, Robert F; Wagner, Henry N.; Tamminga, Carol A.

In: Journal of Computer Assisted Tomography, Vol. 17, No. 5, 1993, p. 704-709.

Research output: Contribution to journalArticle

Holcomb, HH, Cascella, NG, Medoff, DR, Gastineau, EA, Loats, H, Thaker, GK, Conley, RR, Dannals, RF, Wagner, HN & Tamminga, CA 1993, 'Pet-fdg test-re test reliability during a visual discrimination task in schizophrenia', Journal of Computer Assisted Tomography, vol. 17, no. 5, pp. 704-709.
Holcomb HH, Cascella NG, Medoff DR, Gastineau EA, Loats H, Thaker GK et al. Pet-fdg test-re test reliability during a visual discrimination task in schizophrenia. Journal of Computer Assisted Tomography. 1993;17(5):704-709.
Holcomb, Henry H. ; Cascella, Nicola G. ; Medoff, Deborah R. ; Gastineau, Edward A. ; Loats, Harry ; Thaker, Gunvant K. ; Conley, Robert R. ; Dannals, Robert F ; Wagner, Henry N. ; Tamminga, Carol A. / Pet-fdg test-re test reliability during a visual discrimination task in schizophrenia. In: Journal of Computer Assisted Tomography. 1993 ; Vol. 17, No. 5. pp. 704-709.
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AU - Loats, Harry

AU - Thaker, Gunvant K.

AU - Conley, Robert R.

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