Abstract
Objective: Reliability of assessment is important in any kind of neuropsychiatric study, but is particularly pivotal in schizophrenia research where symptom instability is common. Materials and Methods: Two fluorodeoxyglucose PET scans, 1 week apart, were carried out in schizophrenic patients while they were performing a simple visual discrimination task. Subject and scan conditions were held constant. Regional metabolic rates of glucose utilization were calculated as absolute and scaled; they were compared using correlational statistics. Results: Average differences between scans were 5-9% for the parietal and occipital cortices, but 1-3% for other cortical areas, differences comparable with reported variances in normal controls. Conclusion: These results suggest that test-retest variance in metabolic im-aging in schizophrenia is relatively low and that task performance increases metabolic stability in brain areas unrelated to task performance.
Original language | English (US) |
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Pages (from-to) | 704-709 |
Number of pages | 6 |
Journal | Journal of computer assisted tomography |
Volume | 17 |
Issue number | 5 |
DOIs | |
State | Published - 1993 |
Keywords
- Emission computed tomography
- Fluorodeoxyglucose (FDG)
- Glucose
- Metabolism
- Schizophrenia
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging