Pertussis toxin inhibits endothelium-dependent relaxations evoked by fluoride

Nicholas A. Flavahan, Paul M. Vanhoutte

Research output: Contribution to journalArticlepeer-review

Abstract

Fluoride is a direct activator of G-proteins. In isolated rings of canine coronary artery, fluoride caused relaxation of rings with endothelium, but only slight contraction of rings denuded of endothelium. The endothelium-dependent relaxations to fluoride were inhibited by pertussis toxin, an inhibitor of G-proteins, or by methylene blue, an inhibitor of soluble guanylate cyclase. Therefore, fluoride causes endothelium-dependent relaxations in part by activating a pertussis toxin-sensitive G-protein in the endothelial cells.

Original languageEnglish (US)
Pages (from-to)121-124
Number of pages4
JournalEuropean Journal of Pharmacology
Volume178
Issue number1
DOIs
StatePublished - Mar 13 1990
Externally publishedYes

Keywords

  • Bacterial toxins
  • EDRF
  • Endothelium-derived relaxing factor
  • G-proteins
  • guanine nucleotide regulatory proteins

ASJC Scopus subject areas

  • Pharmacology

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