Pertussis-Associated Hospitalizations in American Indian and Alaska Native Infants

Trudy V. Murphy, Shamsuzzoha B. Syed, Robert C. Holman, Dana L. Haberling, Rosalyn J. Singleton, Claudia Angelica Steiner, Edna L. Paisano, James E. Cheek

Research output: Contribution to journalArticle

Abstract

Objective: To investigate the burden of pertussis in American Indian and Alaska Native (AI/AN) infants. Study design: AI/AN pertussis-associated hospitalizations between 1980 and 2004 were evaluated using Indian Health Service (IHS)/tribal inpatient data, which include all reported hospitalizations within the IHS/tribal health care system. Results: Between 1980 and 2004, 483 pertussis-associated hospitalizations in AI/AN infants were documented; 88% of cases involved infants age <6 months. For this entire period, the average annual hospitalization rate was 132.7 per 100,000 AI/AN infants (95% confidence interval [CI] = 121.3 to 145.2), and 234.5 per 100,000 AI/AN infants age <6 months (95% CI = 213.1 to 258.1). Between 2000 and 2004, the annual hospitalization rate was 100.5 per 100,000 AI/AN infants (95% CI = 81.6 to 123.7), which exceeds the estimated 2003 pertussis hospitalization rate of 67.7 per 100,000 in the general US infant population (95% CI = 61.9 to 73.5). The highest pertussis hospitalization rates in 2000 to 2004 were in AI/AN infants in the Alaska and Southwestern IHS regions of the United States. Conclusions: The burden of pertussis in AI/AN infants is high, particularly so in infants age <6 months in the Alaska and the Southwestern IHS regions of the United States. Ensuring implementation of vaccination strategies to reduce the incidence of pertussis in AI/AN, infants, adolescents, and adults alike is warranted to reduce the burden of pertussis in AI/AN infants.

Original languageEnglish (US)
Pages (from-to)839-843
Number of pages5
JournalJournal of Pediatrics
Volume152
Issue number6
DOIs
StatePublished - Jun 2008
Externally publishedYes

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North American Indians
Whooping Cough
Hospitalization
United States Indian Health Service
Confidence Intervals
Alaska Natives
Inpatients
Vaccination

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Murphy, T. V., Syed, S. B., Holman, R. C., Haberling, D. L., Singleton, R. J., Steiner, C. A., ... Cheek, J. E. (2008). Pertussis-Associated Hospitalizations in American Indian and Alaska Native Infants. Journal of Pediatrics, 152(6), 839-843. https://doi.org/10.1016/j.jpeds.2007.11.046

Pertussis-Associated Hospitalizations in American Indian and Alaska Native Infants. / Murphy, Trudy V.; Syed, Shamsuzzoha B.; Holman, Robert C.; Haberling, Dana L.; Singleton, Rosalyn J.; Steiner, Claudia Angelica; Paisano, Edna L.; Cheek, James E.

In: Journal of Pediatrics, Vol. 152, No. 6, 06.2008, p. 839-843.

Research output: Contribution to journalArticle

Murphy, TV, Syed, SB, Holman, RC, Haberling, DL, Singleton, RJ, Steiner, CA, Paisano, EL & Cheek, JE 2008, 'Pertussis-Associated Hospitalizations in American Indian and Alaska Native Infants', Journal of Pediatrics, vol. 152, no. 6, pp. 839-843. https://doi.org/10.1016/j.jpeds.2007.11.046
Murphy TV, Syed SB, Holman RC, Haberling DL, Singleton RJ, Steiner CA et al. Pertussis-Associated Hospitalizations in American Indian and Alaska Native Infants. Journal of Pediatrics. 2008 Jun;152(6):839-843. https://doi.org/10.1016/j.jpeds.2007.11.046
Murphy, Trudy V. ; Syed, Shamsuzzoha B. ; Holman, Robert C. ; Haberling, Dana L. ; Singleton, Rosalyn J. ; Steiner, Claudia Angelica ; Paisano, Edna L. ; Cheek, James E. / Pertussis-Associated Hospitalizations in American Indian and Alaska Native Infants. In: Journal of Pediatrics. 2008 ; Vol. 152, No. 6. pp. 839-843.
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abstract = "Objective: To investigate the burden of pertussis in American Indian and Alaska Native (AI/AN) infants. Study design: AI/AN pertussis-associated hospitalizations between 1980 and 2004 were evaluated using Indian Health Service (IHS)/tribal inpatient data, which include all reported hospitalizations within the IHS/tribal health care system. Results: Between 1980 and 2004, 483 pertussis-associated hospitalizations in AI/AN infants were documented; 88{\%} of cases involved infants age <6 months. For this entire period, the average annual hospitalization rate was 132.7 per 100,000 AI/AN infants (95{\%} confidence interval [CI] = 121.3 to 145.2), and 234.5 per 100,000 AI/AN infants age <6 months (95{\%} CI = 213.1 to 258.1). Between 2000 and 2004, the annual hospitalization rate was 100.5 per 100,000 AI/AN infants (95{\%} CI = 81.6 to 123.7), which exceeds the estimated 2003 pertussis hospitalization rate of 67.7 per 100,000 in the general US infant population (95{\%} CI = 61.9 to 73.5). The highest pertussis hospitalization rates in 2000 to 2004 were in AI/AN infants in the Alaska and Southwestern IHS regions of the United States. Conclusions: The burden of pertussis in AI/AN infants is high, particularly so in infants age <6 months in the Alaska and the Southwestern IHS regions of the United States. Ensuring implementation of vaccination strategies to reduce the incidence of pertussis in AI/AN, infants, adolescents, and adults alike is warranted to reduce the burden of pertussis in AI/AN infants.",
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AU - Singleton, Rosalyn J.

AU - Steiner, Claudia Angelica

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AU - Cheek, James E.

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