Perturbed meibomian gland and tarsal plate morphogenesis by excess TGFα in eyelid stroma

Fei Dong, Chia Yang Liu, Yong Yuan, Yujin Zhang, Wei Li, Mindy Call, Liyun Zhang, Yongxiong Chen, Zuguo Liu, Winston W.Y. Kao

Research output: Contribution to journalArticlepeer-review

Abstract

Transforming growth factor alpha (TGFα) belongs to the epidermal growth factor (EGF) family and is known to play an important role during eyelid morphogenesis. In this study, we showed that ectopic expression of TGFα in the stroma of Kera-rtTA/tet-O-TGFα bitransgenic mice results in precocious eye opening, abnormal morphogenesis of the meibomian gland, tendon and tarsal plate malformation and epithelium hyperplasia. TGFα did not change proliferation and differentiation of meibocytes, but promoted proliferation and inhibited differentiation of the tarsal plate tenocytes. These results suggest that proper formation of the tendon and tarsal plate in the mouse eyelid is required for normal morphogenesis of the meibomian gland.

Original languageEnglish (US)
Pages (from-to)147-157
Number of pages11
JournalDevelopmental biology
Volume406
Issue number2
DOIs
StatePublished - Oct 15 2015

Keywords

  • ECM
  • Eyelid development
  • Eyelid tendon
  • Meibomian gland morphogenesis
  • TGFα
  • Tarsal plate

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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