Abstract
Transforming growth factor alpha (TGFα) belongs to the epidermal growth factor (EGF) family and is known to play an important role during eyelid morphogenesis. In this study, we showed that ectopic expression of TGFα in the stroma of Kera-rtTA/tet-O-TGFα bitransgenic mice results in precocious eye opening, abnormal morphogenesis of the meibomian gland, tendon and tarsal plate malformation and epithelium hyperplasia. TGFα did not change proliferation and differentiation of meibocytes, but promoted proliferation and inhibited differentiation of the tarsal plate tenocytes. These results suggest that proper formation of the tendon and tarsal plate in the mouse eyelid is required for normal morphogenesis of the meibomian gland.
Original language | English (US) |
---|---|
Pages (from-to) | 147-157 |
Number of pages | 11 |
Journal | Developmental biology |
Volume | 406 |
Issue number | 2 |
DOIs | |
State | Published - Oct 15 2015 |
Keywords
- ECM
- Eyelid development
- Eyelid tendon
- Meibomian gland morphogenesis
- TGFα
- Tarsal plate
ASJC Scopus subject areas
- Molecular Biology
- Developmental Biology
- Cell Biology