TY - JOUR
T1 - Perspectives on transdermal scopolamine for the treatment of postoperative nausea and vomiting
AU - Pergolizzi, Joseph V.
AU - Philip, Beverly K.
AU - Leslie, John B.
AU - Taylor, Robert
AU - Raffa, Robert B.
PY - 2012/6
Y1 - 2012/6
N2 - Transdermal scopolamine, a patch system that delivers 1.5 mg of scopolamine gradually over 72 hours following an initial bolus, was approved in the United States in 2001 for the prevention of postoperative nausea and vomiting (PONV) in adults. Scopolamine (hyoscine) is a selective competitive anatagonist of muscarinic cholinergic receptors. Low serum concentrations of scopolamine produce an antiemetic effect. Transdermal scopolamine is effective in preventing PONV versus placebo [relative risk (RR)=0.77, 95% confidence interval (CI), 0.61-0.98, P = 0.03] and a significantly reduced risk for postoperative nausea (RR=0.59, 95% CI, 0.48-0.73, P <0.001), postoperative vomiting (RR=0.68, 95% CI, 0.61-0.76, P <0.001), and PONV (RR 0.73, 95% CI, 0.60-0.88, P = 001) in the first 24 hours after the start of anesthesia.
AB - Transdermal scopolamine, a patch system that delivers 1.5 mg of scopolamine gradually over 72 hours following an initial bolus, was approved in the United States in 2001 for the prevention of postoperative nausea and vomiting (PONV) in adults. Scopolamine (hyoscine) is a selective competitive anatagonist of muscarinic cholinergic receptors. Low serum concentrations of scopolamine produce an antiemetic effect. Transdermal scopolamine is effective in preventing PONV versus placebo [relative risk (RR)=0.77, 95% confidence interval (CI), 0.61-0.98, P = 0.03] and a significantly reduced risk for postoperative nausea (RR=0.59, 95% CI, 0.48-0.73, P <0.001), postoperative vomiting (RR=0.68, 95% CI, 0.61-0.76, P <0.001), and PONV (RR 0.73, 95% CI, 0.60-0.88, P = 001) in the first 24 hours after the start of anesthesia.
KW - Antiemetics
KW - Postdischarge nausea and vomiting
KW - Postoperative nausea and vomiting
KW - Transdermal scopolamine
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U2 - 10.1016/j.jclinane.2011.07.019
DO - 10.1016/j.jclinane.2011.07.019
M3 - Article
C2 - 22608591
AN - SCOPUS:84861171490
SN - 0952-8180
VL - 24
SP - 334
EP - 345
JO - Journal of Clinical Anesthesia
JF - Journal of Clinical Anesthesia
IS - 4
ER -