Perspectives on transdermal scopolamine for the treatment of postoperative nausea and vomiting

Joseph V. Pergolizzi, Beverly K. Philip, John B. Leslie, Robert Taylor, Robert B. Raffa

Research output: Contribution to journalArticle

Abstract

Transdermal scopolamine, a patch system that delivers 1.5 mg of scopolamine gradually over 72 hours following an initial bolus, was approved in the United States in 2001 for the prevention of postoperative nausea and vomiting (PONV) in adults. Scopolamine (hyoscine) is a selective competitive anatagonist of muscarinic cholinergic receptors. Low serum concentrations of scopolamine produce an antiemetic effect. Transdermal scopolamine is effective in preventing PONV versus placebo [relative risk (RR)=0.77, 95% confidence interval (CI), 0.61-0.98, P = 0.03] and a significantly reduced risk for postoperative nausea (RR=0.59, 95% CI, 0.48-0.73, P <0.001), postoperative vomiting (RR=0.68, 95% CI, 0.61-0.76, P <0.001), and PONV (RR 0.73, 95% CI, 0.60-0.88, P = 001) in the first 24 hours after the start of anesthesia.

Original languageEnglish (US)
Pages (from-to)334-345
Number of pages12
JournalJournal of Clinical Anesthesia
Volume24
Issue number4
DOIs
StatePublished - Jun 2012

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Keywords

  • Antiemetics
  • Postdischarge nausea and vomiting
  • Postoperative nausea and vomiting
  • Transdermal scopolamine

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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