Perspectives for Preventive and Therapeutic HPV Vaccines

Ken Lin, Kimberley Doolan, Chien Fu Hung, T. C. Wu

Research output: Contribution to journalReview article

Abstract

Human Papillomavirus (HPV) has been associated with several human cancers, including cervical cancer, vulvar cancer, vaginal and anal cancer, and a subset of head and neck cancers. Thus effective vaccination against HPV provides an opportunity to reduce the morbidity and mortality associated with HPV. The Food and Drug Administration of the United States has approved two preventive vaccines to limit the spread of HPV. However, these are unlikely to impact upon HPV prevalence and cervical cancer rates for many years. Furthermore, preventive vaccines do not exert therapeutic effects on pre-existing HPV infections and HPV-associated lesions. In order to further impact upon the burden of HPV infections worldwide, therapeutic vaccines are being developed. These vaccines aim to generate a cell-mediated immune response to infected cells. This review discusses current preventive and therapeutic HPV vaccines and their future directions.

Original languageEnglish (US)
Pages (from-to)4-24
Number of pages21
JournalJournal of the Formosan Medical Association
Volume109
Issue number1
DOIs
StatePublished - Jan 1 2010

Keywords

  • HPV
  • HPV E6 E7
  • HPV L1 L2
  • cervical cancer
  • preventive vaccines
  • therapeutic vaccines

ASJC Scopus subject areas

  • Medicine(all)

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