Personalizing the Management of Pneumonia

Samir Gautam, Lokesh Sharma, Charles S. Dela Cruz

Research output: Contribution to journalReview article

Abstract

Pneumonia is a highly prevalent disease with considerable morbidity and mortality. However, diagnosis and therapy still rely on antiquated methods, leading to the vast overuse of antimicrobials, which carries risks for both society and the individual. Furthermore, outcomes in severe pneumonia remain poor. Genomic techniques have the potential to transform the management of pneumonia through deep characterization of pathogens as well as the host response to infection. This characterization will enable the delivery of selective antimicrobials and immunomodulatory therapy that will help to offset the disorder associated with overexuberant immune responses.

Original languageEnglish (US)
Pages (from-to)871-900
Number of pages30
JournalClinics in Chest Medicine
Volume39
Issue number4
DOIs
StatePublished - Dec 1 2018
Externally publishedYes

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Keywords

  • Antibiotic resistance
  • Immunomodulation
  • Individualized
  • Personalized
  • Pneumonia
  • Precision

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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