Abstract
Patient-specific ex vivo drug sensitivity and resistance screening can identify rational drug candidates for the testing of personalized targeted therapy. An iterative approach of genomic and drug susceptibility characterization at sequential time points during clinical trials of targeted therapy in acute myeloid leukemia may be useful both for characterizing mechanisms of resistance and clonal evolution and also for identification of novel therapeutic targets and drug combinations.
Original language | English (US) |
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Pages (from-to) | 1336-1338 |
Number of pages | 3 |
Journal | Cancer discovery |
Volume | 3 |
Issue number | 12 |
DOIs | |
State | Published - Dec 2013 |
ASJC Scopus subject areas
- Oncology