Personalized management of atrial fibrillation: Proceedings from the fourth Atrial Fibrillation competence NETwork/European Heart Rhythm Association consensus conference.

Paulus Kirchhof, Günter Breithardt, Etienne Aliot, Sana Al Khatib, Stavros Apostolakis, Angelo Auricchio, Christophe Bailleul, Jeroen Bax, Gerlinde Benninger, Carina Blomstrom-Lundqvist, Lucas Boersma, Giuseppe Boriani, Axel Brandes, Helen Brown, Martina Brueckmann, Hugh Calkins, Barbara Casadei, Andreas Clemens, Harry Crijns, Roland DerwandDobromir Dobrev, Michael Ezekowitz, Thomas Fetsch, Andrea Gerth, Anne Gillis, Michele Gulizia, Guido Hack, Laurent Haegeli, Stephane Hatem, Karl Georg Häusler, Hein Heidbüchel, Jessica Hernandez-Brichis, Pierre Jais, Lukas Kappenberger, Joseph Kautzner, Steven Kim, Karl Heinz Kuck, Deirdre Lane, Angelika Leute, Thorsten Lewalter, Ralf Meyer, Lluis Mont, Gregory Moses, Markus Mueller, Felix Münzel, Michael Näbauer, Jens Cosedis Nielsen, Michael Oeff, Ali Oto, Burkert Pieske, Ron Pisters, Tatjana Potpara, Lars Rasmussen, Ursula Ravens, James Reiffel, Isabelle Richard-Lordereau, Herbert Schäfer, Ulrich Schotten, Wim Stegink, Kenneth Stein, Gerhard Steinbeck, Lukasz Szumowski, Luigi Tavazzi, Sakis Themistoclakis, Karen Thomitzek, Isabelle C. Van Gelder, Berndt von Stritzky, Alphons Vincent, David Werring, Stephan Willems, Gregory Y H Lip, A. John Camm

Research output: Contribution to journalArticle

Abstract

The management of atrial fibrillation (AF) has seen marked changes in past years, with the introduction of new oral anticoagulants, new antiarrhythmic drugs, and the emergence of catheter ablation as a common intervention for rhythm control. Furthermore, new technologies enhance our ability to detect AF. Most clinical management decisions in AF patients can be based on validated parameters that encompass type of presentation, clinical factors, electrocardiogram analysis, and cardiac imaging. Despite these advances, patients with AF are still at increased risk for death, stroke, heart failure, and hospitalizations. During the fourth Atrial Fibrillation competence NETwork/European Heart Rhythm Association (AFNET/EHRA) consensus conference, we identified the following opportunities to personalize management of AF in a better manner with a view to improve outcomes by integrating atrial morphology and damage, brain imaging, information on genetic predisposition, systemic or local inflammation, and markers for cardiac strain. Each of these promising avenues requires validation in the context of existing risk factors in patients. More importantly, a new taxonomy of AF may be needed based on the pathophysiological type of AF to allow personalized management of AF to come to full fruition. Continued translational research efforts are needed to personalize management of this prevalent disease in a better manner. All the efforts are expected to improve the management of patients with AF based on personalized therapy.

Original languageEnglish (US)
Pages (from-to)1540-1556
Number of pages17
JournalEuropace
Volume15
Issue number11
StatePublished - Nov 2013

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Mental Competency
Atrial Fibrillation
Consensus
Aptitude
Translational Medical Research
Catheter Ablation
Anti-Arrhythmia Agents
Genetic Predisposition to Disease
Disease Management
Neuroimaging
Anticoagulants
Statistical Factor Analysis
Electrocardiography
Hospitalization
Heart Failure
Stroke
Inflammation
Technology

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kirchhof, P., Breithardt, G., Aliot, E., Al Khatib, S., Apostolakis, S., Auricchio, A., ... Camm, A. J. (2013). Personalized management of atrial fibrillation: Proceedings from the fourth Atrial Fibrillation competence NETwork/European Heart Rhythm Association consensus conference. Europace, 15(11), 1540-1556.

Personalized management of atrial fibrillation : Proceedings from the fourth Atrial Fibrillation competence NETwork/European Heart Rhythm Association consensus conference. / Kirchhof, Paulus; Breithardt, Günter; Aliot, Etienne; Al Khatib, Sana; Apostolakis, Stavros; Auricchio, Angelo; Bailleul, Christophe; Bax, Jeroen; Benninger, Gerlinde; Blomstrom-Lundqvist, Carina; Boersma, Lucas; Boriani, Giuseppe; Brandes, Axel; Brown, Helen; Brueckmann, Martina; Calkins, Hugh; Casadei, Barbara; Clemens, Andreas; Crijns, Harry; Derwand, Roland; Dobrev, Dobromir; Ezekowitz, Michael; Fetsch, Thomas; Gerth, Andrea; Gillis, Anne; Gulizia, Michele; Hack, Guido; Haegeli, Laurent; Hatem, Stephane; Georg Häusler, Karl; Heidbüchel, Hein; Hernandez-Brichis, Jessica; Jais, Pierre; Kappenberger, Lukas; Kautzner, Joseph; Kim, Steven; Kuck, Karl Heinz; Lane, Deirdre; Leute, Angelika; Lewalter, Thorsten; Meyer, Ralf; Mont, Lluis; Moses, Gregory; Mueller, Markus; Münzel, Felix; Näbauer, Michael; Nielsen, Jens Cosedis; Oeff, Michael; Oto, Ali; Pieske, Burkert; Pisters, Ron; Potpara, Tatjana; Rasmussen, Lars; Ravens, Ursula; Reiffel, James; Richard-Lordereau, Isabelle; Schäfer, Herbert; Schotten, Ulrich; Stegink, Wim; Stein, Kenneth; Steinbeck, Gerhard; Szumowski, Lukasz; Tavazzi, Luigi; Themistoclakis, Sakis; Thomitzek, Karen; Van Gelder, Isabelle C.; von Stritzky, Berndt; Vincent, Alphons; Werring, David; Willems, Stephan; Lip, Gregory Y H; Camm, A. John.

In: Europace, Vol. 15, No. 11, 11.2013, p. 1540-1556.

Research output: Contribution to journalArticle

Kirchhof, P, Breithardt, G, Aliot, E, Al Khatib, S, Apostolakis, S, Auricchio, A, Bailleul, C, Bax, J, Benninger, G, Blomstrom-Lundqvist, C, Boersma, L, Boriani, G, Brandes, A, Brown, H, Brueckmann, M, Calkins, H, Casadei, B, Clemens, A, Crijns, H, Derwand, R, Dobrev, D, Ezekowitz, M, Fetsch, T, Gerth, A, Gillis, A, Gulizia, M, Hack, G, Haegeli, L, Hatem, S, Georg Häusler, K, Heidbüchel, H, Hernandez-Brichis, J, Jais, P, Kappenberger, L, Kautzner, J, Kim, S, Kuck, KH, Lane, D, Leute, A, Lewalter, T, Meyer, R, Mont, L, Moses, G, Mueller, M, Münzel, F, Näbauer, M, Nielsen, JC, Oeff, M, Oto, A, Pieske, B, Pisters, R, Potpara, T, Rasmussen, L, Ravens, U, Reiffel, J, Richard-Lordereau, I, Schäfer, H, Schotten, U, Stegink, W, Stein, K, Steinbeck, G, Szumowski, L, Tavazzi, L, Themistoclakis, S, Thomitzek, K, Van Gelder, IC, von Stritzky, B, Vincent, A, Werring, D, Willems, S, Lip, GYH & Camm, AJ 2013, 'Personalized management of atrial fibrillation: Proceedings from the fourth Atrial Fibrillation competence NETwork/European Heart Rhythm Association consensus conference.', Europace, vol. 15, no. 11, pp. 1540-1556.
Kirchhof, Paulus ; Breithardt, Günter ; Aliot, Etienne ; Al Khatib, Sana ; Apostolakis, Stavros ; Auricchio, Angelo ; Bailleul, Christophe ; Bax, Jeroen ; Benninger, Gerlinde ; Blomstrom-Lundqvist, Carina ; Boersma, Lucas ; Boriani, Giuseppe ; Brandes, Axel ; Brown, Helen ; Brueckmann, Martina ; Calkins, Hugh ; Casadei, Barbara ; Clemens, Andreas ; Crijns, Harry ; Derwand, Roland ; Dobrev, Dobromir ; Ezekowitz, Michael ; Fetsch, Thomas ; Gerth, Andrea ; Gillis, Anne ; Gulizia, Michele ; Hack, Guido ; Haegeli, Laurent ; Hatem, Stephane ; Georg Häusler, Karl ; Heidbüchel, Hein ; Hernandez-Brichis, Jessica ; Jais, Pierre ; Kappenberger, Lukas ; Kautzner, Joseph ; Kim, Steven ; Kuck, Karl Heinz ; Lane, Deirdre ; Leute, Angelika ; Lewalter, Thorsten ; Meyer, Ralf ; Mont, Lluis ; Moses, Gregory ; Mueller, Markus ; Münzel, Felix ; Näbauer, Michael ; Nielsen, Jens Cosedis ; Oeff, Michael ; Oto, Ali ; Pieske, Burkert ; Pisters, Ron ; Potpara, Tatjana ; Rasmussen, Lars ; Ravens, Ursula ; Reiffel, James ; Richard-Lordereau, Isabelle ; Schäfer, Herbert ; Schotten, Ulrich ; Stegink, Wim ; Stein, Kenneth ; Steinbeck, Gerhard ; Szumowski, Lukasz ; Tavazzi, Luigi ; Themistoclakis, Sakis ; Thomitzek, Karen ; Van Gelder, Isabelle C. ; von Stritzky, Berndt ; Vincent, Alphons ; Werring, David ; Willems, Stephan ; Lip, Gregory Y H ; Camm, A. John. / Personalized management of atrial fibrillation : Proceedings from the fourth Atrial Fibrillation competence NETwork/European Heart Rhythm Association consensus conference. In: Europace. 2013 ; Vol. 15, No. 11. pp. 1540-1556.
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abstract = "The management of atrial fibrillation (AF) has seen marked changes in past years, with the introduction of new oral anticoagulants, new antiarrhythmic drugs, and the emergence of catheter ablation as a common intervention for rhythm control. Furthermore, new technologies enhance our ability to detect AF. Most clinical management decisions in AF patients can be based on validated parameters that encompass type of presentation, clinical factors, electrocardiogram analysis, and cardiac imaging. Despite these advances, patients with AF are still at increased risk for death, stroke, heart failure, and hospitalizations. During the fourth Atrial Fibrillation competence NETwork/European Heart Rhythm Association (AFNET/EHRA) consensus conference, we identified the following opportunities to personalize management of AF in a better manner with a view to improve outcomes by integrating atrial morphology and damage, brain imaging, information on genetic predisposition, systemic or local inflammation, and markers for cardiac strain. Each of these promising avenues requires validation in the context of existing risk factors in patients. More importantly, a new taxonomy of AF may be needed based on the pathophysiological type of AF to allow personalized management of AF to come to full fruition. Continued translational research efforts are needed to personalize management of this prevalent disease in a better manner. All the efforts are expected to improve the management of patients with AF based on personalized therapy.",
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T2 - Proceedings from the fourth Atrial Fibrillation competence NETwork/European Heart Rhythm Association consensus conference.

AU - Kirchhof, Paulus

AU - Breithardt, Günter

AU - Aliot, Etienne

AU - Al Khatib, Sana

AU - Apostolakis, Stavros

AU - Auricchio, Angelo

AU - Bailleul, Christophe

AU - Bax, Jeroen

AU - Benninger, Gerlinde

AU - Blomstrom-Lundqvist, Carina

AU - Boersma, Lucas

AU - Boriani, Giuseppe

AU - Brandes, Axel

AU - Brown, Helen

AU - Brueckmann, Martina

AU - Calkins, Hugh

AU - Casadei, Barbara

AU - Clemens, Andreas

AU - Crijns, Harry

AU - Derwand, Roland

AU - Dobrev, Dobromir

AU - Ezekowitz, Michael

AU - Fetsch, Thomas

AU - Gerth, Andrea

AU - Gillis, Anne

AU - Gulizia, Michele

AU - Hack, Guido

AU - Haegeli, Laurent

AU - Hatem, Stephane

AU - Georg Häusler, Karl

AU - Heidbüchel, Hein

AU - Hernandez-Brichis, Jessica

AU - Jais, Pierre

AU - Kappenberger, Lukas

AU - Kautzner, Joseph

AU - Kim, Steven

AU - Kuck, Karl Heinz

AU - Lane, Deirdre

AU - Leute, Angelika

AU - Lewalter, Thorsten

AU - Meyer, Ralf

AU - Mont, Lluis

AU - Moses, Gregory

AU - Mueller, Markus

AU - Münzel, Felix

AU - Näbauer, Michael

AU - Nielsen, Jens Cosedis

AU - Oeff, Michael

AU - Oto, Ali

AU - Pieske, Burkert

AU - Pisters, Ron

AU - Potpara, Tatjana

AU - Rasmussen, Lars

AU - Ravens, Ursula

AU - Reiffel, James

AU - Richard-Lordereau, Isabelle

AU - Schäfer, Herbert

AU - Schotten, Ulrich

AU - Stegink, Wim

AU - Stein, Kenneth

AU - Steinbeck, Gerhard

AU - Szumowski, Lukasz

AU - Tavazzi, Luigi

AU - Themistoclakis, Sakis

AU - Thomitzek, Karen

AU - Van Gelder, Isabelle C.

AU - von Stritzky, Berndt

AU - Vincent, Alphons

AU - Werring, David

AU - Willems, Stephan

AU - Lip, Gregory Y H

AU - Camm, A. John

PY - 2013/11

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