Personality and risk of Alzheimer's disease: New data and meta-analysis

Antonio Terracciano, Angelina R. Sutin, Yang An, Richard J. O'Brien, Luigi Ferrucci, Alan B. Zonderman, Susan M. Resnick

Research output: Contribution to journalArticle

Abstract

Background: We examine whether broad factors and specific facets of personality are associated with increased risk of incident Alzheimer's disease (AD) in a long-run longitudinal study and a meta-analysis of published studies. Methods: Participants (n = 1671) were monitored for up to 22 years from a baseline personality assessment. The meta-analysis pooled results from up to five prospective studies (n = 5054). Results: Individuals with scores in the top quartile of neuroticism (hazard ratio = 3.1; 95% confidence interval = 1.6-6.0) or the lowest quartile of conscientiousness (hazard ratio = 3.3; 95% confidence interval = 1.4-7.4) had a threefold increased risk of incident AD. Among the components of these traits, self-discipline and depression had the strongest associations with incident AD. The meta-analysis confirmed the associations of neuroticism (P = 2 × 10-9) and conscientiousness (P = 2 × 10-6), along with weaker effects for openness and agreeableness (P

Original languageEnglish (US)
Pages (from-to)179-186
Number of pages8
JournalAlzheimer's and Dementia
Volume10
Issue number2
DOIs
StatePublished - 2014

Fingerprint

Personality
Meta-Analysis
Alzheimer Disease
Confidence Intervals
Personality Assessment
Longitudinal Studies
Prospective Studies
Depression
Neuroticism

Keywords

  • Alzheimer's disease
  • Anxiety
  • APOE
  • Conscientiousness
  • Dementia
  • Depression
  • Meta-analysis
  • Neuroticism
  • Observational prospective study
  • Order
  • Self-discipline

ASJC Scopus subject areas

  • Clinical Neurology
  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Epidemiology
  • Health Policy

Cite this

Terracciano, A., Sutin, A. R., An, Y., O'Brien, R. J., Ferrucci, L., Zonderman, A. B., & Resnick, S. M. (2014). Personality and risk of Alzheimer's disease: New data and meta-analysis. Alzheimer's and Dementia, 10(2), 179-186. https://doi.org/10.1016/j.jalz.2013.03.002

Personality and risk of Alzheimer's disease : New data and meta-analysis. / Terracciano, Antonio; Sutin, Angelina R.; An, Yang; O'Brien, Richard J.; Ferrucci, Luigi; Zonderman, Alan B.; Resnick, Susan M.

In: Alzheimer's and Dementia, Vol. 10, No. 2, 2014, p. 179-186.

Research output: Contribution to journalArticle

Terracciano, A, Sutin, AR, An, Y, O'Brien, RJ, Ferrucci, L, Zonderman, AB & Resnick, SM 2014, 'Personality and risk of Alzheimer's disease: New data and meta-analysis', Alzheimer's and Dementia, vol. 10, no. 2, pp. 179-186. https://doi.org/10.1016/j.jalz.2013.03.002
Terracciano A, Sutin AR, An Y, O'Brien RJ, Ferrucci L, Zonderman AB et al. Personality and risk of Alzheimer's disease: New data and meta-analysis. Alzheimer's and Dementia. 2014;10(2):179-186. https://doi.org/10.1016/j.jalz.2013.03.002
Terracciano, Antonio ; Sutin, Angelina R. ; An, Yang ; O'Brien, Richard J. ; Ferrucci, Luigi ; Zonderman, Alan B. ; Resnick, Susan M. / Personality and risk of Alzheimer's disease : New data and meta-analysis. In: Alzheimer's and Dementia. 2014 ; Vol. 10, No. 2. pp. 179-186.
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