Personality and differential treatment response in major depression: A randomized controlled trial comparing cognitive-behavioural therapy and pharmacotherapy

R. Michael Bagby, Lena C. Quilty, Zindel V. Segal, Carolina C. McBride, Sidney H. Kennedy, Paul T. Costa

Research output: Contribution to journalArticle

Abstract

Objective: Effective treatments for major depressive disorder exist, yet some patients fail to respond, or achieve only partial response. One approach to optimizing treatment success is to identify which patients are more likely to respond best to which treatments. The objective of this investigation was to determine if patient personality characteristics are predictive of response to either cognitive-behavioural therapy (CBT) or pharmacotherapy (PHT). Method: Depressed patients completed the Revised NEO Personality Inventory, which measures the higher-order domain and lower-order facet traits of the Five-Factor Model of Personality, and were randomized to receive either CBT or PHT. Result: Four personality traits - the higher-order domain neuroticism and 3 lower-order facet traits: trust, straightforwardness, and tendermindedness - were able to distinguish a differential response rate to CBT, compared with PHT. Conclusion: The assessment of patient dimensional personality traits can assist in the selection and optimization of treatment response for depressed patients.

Original languageEnglish (US)
Pages (from-to)361-370
Number of pages10
JournalCanadian Journal of Psychiatry
Volume53
Issue number6
DOIs
StatePublished - Jun 2008

Keywords

  • Depression
  • Personality
  • Pharmacotherapy
  • Psychotherapy
  • Treatment selection

ASJC Scopus subject areas

  • Psychiatry and Mental health

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