Person-to-person transmission of Nipah virus in a Bangladeshi community

Emily S. Gurley; Joel M. Montgomery; M. Jahangir Hossain; Michael Bell; Abul Kalam Azad; Mohammed Rafiqul Islam; Mohammed Abdur Rahim Molla; Darin S. Carroll; Thomas G. Ksiazek; Paul A. Rota; Luis Lowe; James A. Comer; Pierre Rollin; Markus Czub; Allen Grolla; Heinz Feldmann; Stephen P. Luby; Jennifer L. Woodward; Robert F. Breiman

doi:10.3201/eid1307.061128

Person-to-person transmission of Nipah virus in a Bangladeshi community

Emily S. Gurley, Joel M. Montgomery, M. Jahangir Hossain, Michael Bell, Abul Kalam Azad, Mohammed Rafiqul Islam, Mohammed Abdur Rahim Molla, Darin S. Carroll, Thomas G. Ksiazek, Paul A. Rota, Luis Lowe, James A. Comer, Pierre Rollin, Markus Czub, Allen Grolla, Heinz Feldmann, Stephen P. Luby, Jennifer L. Woodward, Robert F. Breiman

Research output: Contribution to journal › Article › peer-review

257 Scopus citations

Abstract

An encephalitis outbreak was investigated in Faridpur District, Bangladesh, in April-May 2004 to determine the cause of the outbreak and risk factors for disease. Biologic specimens were tested for Nipah virus. Surfaces were evaluated for Nipah virus contamination by using reverse transcription-PCR (RT-PCR). Thirty-six cases of Nipah virus illness were identified; 75% of case-patients died. Multiple peaks of illness occurred, and 33 case-patients had close contact with another Nipah virus patient before their illness. Results from a case-control study showed that contact with 1 patient carried the highest risk for infection (odds ratio 6.7, 95% confidence interval 2.9-16.8, p<0.001). RT-PCR testing of environmental samples confirmed Nipah virus contamination of hospital surfaces. This investigation provides evidence for person-to-person transmission of Nipah virus. Capacity for person-to-person transmission increases the potential for wider spread of this highly lethal pathogen and highlights the need for infection control strategies for resource-poor settings.

Original language	English (US)
Pages (from-to)	1031-1037
Number of pages	7
Journal	Emerging infectious diseases
Volume	13
Issue number	7
DOIs	https://doi.org/10.3201/eid1307.061128
State	Published - Jul 2007
Externally published	Yes

ASJC Scopus subject areas

Epidemiology
Microbiology (medical)
Infectious Diseases

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Gurley, E. S., Montgomery, J. M., Hossain, M. J., Bell, M., Azad, A. K., Islam, M. R., Molla, M. A. R., Carroll, D. S., Ksiazek, T. G., Rota, P. A., Lowe, L., Comer, J. A., Rollin, P., Czub, M., Grolla, A., Feldmann, H., Luby, S. P., Woodward, J. L., & Breiman, R. F. (2007). Person-to-person transmission of Nipah virus in a Bangladeshi community. Emerging infectious diseases, 13(7), 1031-1037. https://doi.org/10.3201/eid1307.061128

Gurley, ES, Montgomery, JM, Hossain, MJ, Bell, M, Azad, AK, Islam, MR, Molla, MAR, Carroll, DS, Ksiazek, TG, Rota, PA, Lowe, L, Comer, JA, Rollin, P, Czub, M, Grolla, A, Feldmann, H, Luby, SP, Woodward, JL & Breiman, RF 2007, 'Person-to-person transmission of Nipah virus in a Bangladeshi community', Emerging infectious diseases, vol. 13, no. 7, pp. 1031-1037. https://doi.org/10.3201/eid1307.061128

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title = "Person-to-person transmission of Nipah virus in a Bangladeshi community",

abstract = "An encephalitis outbreak was investigated in Faridpur District, Bangladesh, in April-May 2004 to determine the cause of the outbreak and risk factors for disease. Biologic specimens were tested for Nipah virus. Surfaces were evaluated for Nipah virus contamination by using reverse transcription-PCR (RT-PCR). Thirty-six cases of Nipah virus illness were identified; 75% of case-patients died. Multiple peaks of illness occurred, and 33 case-patients had close contact with another Nipah virus patient before their illness. Results from a case-control study showed that contact with 1 patient carried the highest risk for infection (odds ratio 6.7, 95% confidence interval 2.9-16.8, p<0.001). RT-PCR testing of environmental samples confirmed Nipah virus contamination of hospital surfaces. This investigation provides evidence for person-to-person transmission of Nipah virus. Capacity for person-to-person transmission increases the potential for wider spread of this highly lethal pathogen and highlights the need for infection control strategies for resource-poor settings.",

author = "Gurley, {Emily S.} and Montgomery, {Joel M.} and Hossain, {M. Jahangir} and Michael Bell and Azad, {Abul Kalam} and Islam, {Mohammed Rafiqul} and Molla, {Mohammed Abdur Rahim} and Carroll, {Darin S.} and Ksiazek, {Thomas G.} and Rota, {Paul A.} and Luis Lowe and Comer, {James A.} and Pierre Rollin and Markus Czub and Allen Grolla and Heinz Feldmann and Luby, {Stephen P.} and Woodward, {Jennifer L.} and Breiman, {Robert F.}",

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AU - Lowe, Luis

AU - Comer, James A.

AU - Rollin, Pierre

AU - Czub, Markus

AU - Grolla, Allen

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AU - Woodward, Jennifer L.

AU - Breiman, Robert F.

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Person-to-person transmission of Nipah virus in a Bangladeshi community

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