Persistent Structural Plasticity Optimizes Sensory Information Processing in the Olfactory Bulb

Kurt A. Sailor, Matthew T. Valley, Martin T. Wiechert, Hermann Riecke, Gerald J. Sun, Wayne Adams, James C. Dennis, Shirin Sharafi, Guo li Ming, Hongjun Song, Pierre Marie Lledo

Research output: Contribution to journalArticle

Abstract

In the mammalian brain, the anatomical structure of neural circuits changes little during adulthood. As a result, adult learning and memory are thought to result from specific changes in synaptic strength. A possible exception is the olfactory bulb (OB), where activity guides interneuron turnover throughout adulthood. These adult-born granule cell (GC) interneurons form new GABAergic synapses that have little synaptic strength plasticity. In the face of persistent neuronal and synaptic turnover, how does the OB balance flexibility, as is required for adapting to changing sensory environments, with perceptual stability? Here we show that high dendritic spine turnover is a universal feature of GCs, regardless of their developmental origin and age. We find matching dynamics among postsynaptic sites on the principal neurons receiving the new synaptic inputs. We further demonstrate in silico that this coordinated structural plasticity is consistent with stable, yet flexible, decorrelated sensory representations. Together, our study reveals that persistent, coordinated synaptic structural plasticity between interneurons and principal neurons is a major mode of functional plasticity in the OB. Using in vivo imaging, Sailor and Valley et al. (2016) show matching, robust structural plasticity in olfactory bulb granule and mitral/tufted cell synapses. Computational modeling shows this structural plasticity is compatible with stable memory and high adaptability to changing sensory inputs.

Original languageEnglish (US)
JournalNeuron
DOIs
StateAccepted/In press - Oct 15 2015

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Persistent Structural Plasticity Optimizes Sensory Information Processing in the Olfactory Bulb'. Together they form a unique fingerprint.

  • Cite this

    Sailor, K. A., Valley, M. T., Wiechert, M. T., Riecke, H., Sun, G. J., Adams, W., Dennis, J. C., Sharafi, S., Ming, G. L., Song, H., & Lledo, P. M. (Accepted/In press). Persistent Structural Plasticity Optimizes Sensory Information Processing in the Olfactory Bulb. Neuron. https://doi.org/10.1016/j.neuron.2016.06.004