Persistent oligemia of rat cerebral cortex in the wake of spreading depression

M. Lauritzen, M. B. Jørgensen, N. H. Diemer, A. Gjedde, A. J. Hansen

Research output: Contribution to journalArticle

Abstract

Cerebral blood flow during and after spreading depression (SD) was studied in rat brain by quantitative autoradiography. The rise of cortical blood flow during SD was followed by 20 to 25% reduction below normal after SD, lasting at least an hour. Blood flow in the putamen, thalamus, and hippocampus did not change at any time during or after SD. Previous measurements of cerebral blood flow in humans showed that migraine attacks may be accompanied by wavelike spreading oligemia (Olesen at al., 1981). We speculate that the spreading oligemia of migraine may be a phenomenon physiologically related to the present finding of an oligemia after SD.

Original languageEnglish (US)
Pages (from-to)469-474
Number of pages6
JournalAnnals of Neurology
Volume12
Issue number5
DOIs
StatePublished - 1982
Externally publishedYes

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Cerebrovascular Circulation
Migraine Disorders
Cerebral Cortex
Putamen
Autoradiography
Thalamus
Hippocampus
Brain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Lauritzen, M., Jørgensen, M. B., Diemer, N. H., Gjedde, A., & Hansen, A. J. (1982). Persistent oligemia of rat cerebral cortex in the wake of spreading depression. Annals of Neurology, 12(5), 469-474. https://doi.org/10.1002/ana.410120510

Persistent oligemia of rat cerebral cortex in the wake of spreading depression. / Lauritzen, M.; Jørgensen, M. B.; Diemer, N. H.; Gjedde, A.; Hansen, A. J.

In: Annals of Neurology, Vol. 12, No. 5, 1982, p. 469-474.

Research output: Contribution to journalArticle

Lauritzen, M, Jørgensen, MB, Diemer, NH, Gjedde, A & Hansen, AJ 1982, 'Persistent oligemia of rat cerebral cortex in the wake of spreading depression', Annals of Neurology, vol. 12, no. 5, pp. 469-474. https://doi.org/10.1002/ana.410120510
Lauritzen, M. ; Jørgensen, M. B. ; Diemer, N. H. ; Gjedde, A. ; Hansen, A. J. / Persistent oligemia of rat cerebral cortex in the wake of spreading depression. In: Annals of Neurology. 1982 ; Vol. 12, No. 5. pp. 469-474.
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