Persistent macular thickening after ranibizumab treatment for diabetic macular edema with vision impairment

Susan B Bressler, Allison R. Ayala, Neil M Bressler, Michele Melia, Haijing Qin, Frederick L. Ferris, Christina J. Flaxel, Scott M. Friedman, Adam R. Glassman, Lee M. Jampol, Michael E. Rauser

Research output: Contribution to journalArticle

Abstract

IMPORTANCE: The prevalence of persistent diabetic macular edema (DME) after months of anti-vascular endothelial growth factor therapy and its effect on visual acuity are unknown. OBJECTIVE: To assess subsequent outcomes of eyes with DME persisting for 24 weeks after initiating treatment with 0.5 mg of ranibizumab. DESIGN, SETTING, AND PARTICIPANTS: We performed post hoc, exploratory analyses of a randomized clinical trial from March 20, 2007, through January 29, 2014, from 117 of 296 eyes (39.5%) randomly assigned to receive ranibizumab with persistent DME (central subfield thickness ≥250 μm on time domain optical coherence tomography) through the 24-week visit. INTERVENTIONS: Four monthly intravitreous injections of ranibizumab and then as needed per protocol. MAIN OUTCOMES AND MEASURES: Cumulative 3-year probabilities of chronic persistent DME (failure to achieve a central subfield thickness

Original languageEnglish (US)
Pages (from-to)278-285
Number of pages8
JournalJAMA Ophthalmology
Volume134
Issue number3
DOIs
StatePublished - Mar 1 2016

ASJC Scopus subject areas

  • Ophthalmology

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    Bressler, S. B., Ayala, A. R., Bressler, N. M., Melia, M., Qin, H., Ferris, F. L., Flaxel, C. J., Friedman, S. M., Glassman, A. R., Jampol, L. M., & Rauser, M. E. (2016). Persistent macular thickening after ranibizumab treatment for diabetic macular edema with vision impairment. JAMA Ophthalmology, 134(3), 278-285. https://doi.org/10.1001/jamaophthalmol.2015.5346