Persistent low albumin and temporary vascular access in pediatric patients with SLE on hemodialysis

Research output: Contribution to journalArticlepeer-review

Abstract

Pediatric patients with systemic lupus erythematosus (SLE) often present with significant kidney disease. In a previous cross-sectional analysis, we showed that pediatric patients with ESRD secondary to SLE have lower serum albumin levels and less permanent vascular access for hemodialysis (HD) compared to pediatric patients on HD secondary to other causes. The goal of this longitudinal study was to determine if there was an improvement in these targets over time. To this end, we performed a longitudinal analysis of patients receiving HD in the ESRD Clinical Performance Measures Project 2000-2004 study years, comparing achievement of clinical targets between pediatric patients with SLE and pediatric patients with other causes of ESRD. In the longitudinal follow-up, pediatric patients with SLE were less likely to reach target albumin levels than other children with ESRD maintained on HD [odds ratio (OR) 0.18, 95% confidence interval (CI) 0.09, 0.35] and were less likely to have arteriovenous fistulas or grafts than other pediatric patients (OR 0.45, 95% CI 0.23, 0.89). Pediatric patients with SLE maintained on HD are at particularly high risk for failing to meet some clinical targets that have been associated with improved long-term outcomes in other populations. This is true even as they remain on dialysis over time.

Original languageEnglish (US)
Pages (from-to)1981-1987
Number of pages7
JournalPediatric Nephrology
Volume24
Issue number10
DOIs
StatePublished - 2009

Keywords

  • Albumin
  • Dialysis
  • Pediatrics
  • Systemic lupus erythematosus
  • Vascular access

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

Fingerprint Dive into the research topics of 'Persistent low albumin and temporary vascular access in pediatric patients with SLE on hemodialysis'. Together they form a unique fingerprint.

Cite this