Persistent Interferon Production by Double Negative T Cells and Collapsing Focal Segmental Glomerulosclerosis

Sadichhya Lohani, Mohanraj Sadasivam, Hamid Rabb, Mohamed G. Atta

Research output: Contribution to journalArticlepeer-review

Abstract

Collapsing glomerulopathy has multiple associations, including viral infections, medications like bisphosphonates and interferon, autoimmune diseases, and genetic predisposition. We report a case of collapsing focal segmental glomerulosclerosis associated with persistently high levels of interferon gamma produced by T-cell receptor αβ (+), CD4-CD8-(double negative) T lymphocytes that progressed despite treatment and improvement of other cytokine levels. Double negative T cells are elevated and activated in autoimmune lymphoproliferative syndrome (ALPS). Production of elevated interferon gamma levels from double negative T cells in ALPS despite treatment provides insight to the pathophysiology of collapsing glomerulopathy, guiding future research for collapsing glomerulopathy.

Original languageEnglish (US)
JournalNephron
DOIs
StateAccepted/In press - 2020

ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Physiology (medical)
  • Urology

Fingerprint Dive into the research topics of 'Persistent Interferon Production by Double Negative T Cells and Collapsing Focal Segmental Glomerulosclerosis'. Together they form a unique fingerprint.

Cite this