Persistent Interferon Production by Double Negative T Cells and Collapsing Focal Segmental Glomerulosclerosis

Sadichhya Lohani; Mohanraj Sadasivam; Hamid Rabb; Mohamed G. Atta

doi:10.1159/000510759

Persistent Interferon Production by Double Negative T Cells and Collapsing Focal Segmental Glomerulosclerosis

Sadichhya Lohani, Mohanraj Sadasivam, Hamid Rabb, Mohamed G. Atta

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Collapsing glomerulopathy has multiple associations, including viral infections, medications like bisphosphonates and interferon, autoimmune diseases, and genetic predisposition. We report a case of collapsing focal segmental glomerulosclerosis associated with persistently high levels of interferon gamma produced by T-cell receptor αβ (+), CD4-CD8-(double negative) T lymphocytes that progressed despite treatment and improvement of other cytokine levels. Double negative T cells are elevated and activated in autoimmune lymphoproliferative syndrome (ALPS). Production of elevated interferon gamma levels from double negative T cells in ALPS despite treatment provides insight to the pathophysiology of collapsing glomerulopathy, guiding future research for collapsing glomerulopathy.

Original language	English (US)
Pages (from-to)	85-90
Number of pages	6
Journal	Nephron
Volume	145
Issue number	1
DOIs	https://doi.org/10.1159/000510759
State	Published - Jan 2021

Keywords

Autoimmune lymphoproliferative disorder
Collapsing glomerulopathy
Double negative T cell
Focal segmental glomerulosclerosis
Interferon gamma

ASJC Scopus subject areas

Physiology
Nephrology
Physiology (medical)
Urology

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10.1159/000510759

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title = "Persistent Interferon Production by Double Negative T Cells and Collapsing Focal Segmental Glomerulosclerosis",

abstract = "Collapsing glomerulopathy has multiple associations, including viral infections, medications like bisphosphonates and interferon, autoimmune diseases, and genetic predisposition. We report a case of collapsing focal segmental glomerulosclerosis associated with persistently high levels of interferon gamma produced by T-cell receptor αβ (+), CD4-CD8-(double negative) T lymphocytes that progressed despite treatment and improvement of other cytokine levels. Double negative T cells are elevated and activated in autoimmune lymphoproliferative syndrome (ALPS). Production of elevated interferon gamma levels from double negative T cells in ALPS despite treatment provides insight to the pathophysiology of collapsing glomerulopathy, guiding future research for collapsing glomerulopathy.",

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AU - Rabb, Hamid

AU - Atta, Mohamed G.

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AB - Collapsing glomerulopathy has multiple associations, including viral infections, medications like bisphosphonates and interferon, autoimmune diseases, and genetic predisposition. We report a case of collapsing focal segmental glomerulosclerosis associated with persistently high levels of interferon gamma produced by T-cell receptor αβ (+), CD4-CD8-(double negative) T lymphocytes that progressed despite treatment and improvement of other cytokine levels. Double negative T cells are elevated and activated in autoimmune lymphoproliferative syndrome (ALPS). Production of elevated interferon gamma levels from double negative T cells in ALPS despite treatment provides insight to the pathophysiology of collapsing glomerulopathy, guiding future research for collapsing glomerulopathy.

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KW - Focal segmental glomerulosclerosis

KW - Interferon gamma

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Persistent Interferon Production by Double Negative T Cells and Collapsing Focal Segmental Glomerulosclerosis

Abstract

Keywords

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