Persistent hyperplastic primary vitreous in an adult: Case report with fluorescein angiographic findings

D. K. Gieser, Morton F Goldberg, D. J. Apple, N. A. Hamming, M. H. Kottow

Research output: Contribution to journalArticle

Abstract

Persistent hyperplastic primary vitreous (PHPV) is one of the most serious lesions induced by abnormal development of the embryonic intraocular vasculature. It often progresses to secondary complications such as rupture of the lens capsule and cataract formation, intraocular hemorrhage, secondary glaucoma, tractional retinal folds (with occasional associated detachment), and eventual phtisis bulbi. There have been only a few patients with this condition whose eyes are known to have survived to adulthood. This report describes the clinical and fluorescein angiographic findings of PHPV in an 18-year-old patient. To the best of our knowledge, angiography of the fibrovascular retrolental mass has not been previously reported. The clinical course of this case is unusual in that no catastrophic complication had occurred and no therapeutic intervention was required. The lens resorbed spontaneously, thereby permitting study of the retrolental mass by fluorescein angiography. Fluorescein leakage from the persistent vessels was very slow but present, thus indicating a probable disruption of the endothelial tight junctions of the tunica vasculosa lentis.

Original languageEnglish (US)
Pages (from-to)213-218
Number of pages6
JournalJournal of Pediatric Ophthalmology and Strabismus
Volume15
Issue number4
StatePublished - 1978
Externally publishedYes

Fingerprint

Persistent Hyperplastic Primary Vitreous
Fluorescein
Lenses
Fluorescein Angiography
Tight Junctions
Glaucoma
Cataract
Capsules
Embryonic Development
Rupture
Angiography
Hemorrhage
Therapeutics

ASJC Scopus subject areas

  • Ophthalmology
  • Pediatrics, Perinatology, and Child Health

Cite this

Persistent hyperplastic primary vitreous in an adult : Case report with fluorescein angiographic findings. / Gieser, D. K.; Goldberg, Morton F; Apple, D. J.; Hamming, N. A.; Kottow, M. H.

In: Journal of Pediatric Ophthalmology and Strabismus, Vol. 15, No. 4, 1978, p. 213-218.

Research output: Contribution to journalArticle

@article{a009a14ed67047c197e5c982632d5145,
title = "Persistent hyperplastic primary vitreous in an adult: Case report with fluorescein angiographic findings",
abstract = "Persistent hyperplastic primary vitreous (PHPV) is one of the most serious lesions induced by abnormal development of the embryonic intraocular vasculature. It often progresses to secondary complications such as rupture of the lens capsule and cataract formation, intraocular hemorrhage, secondary glaucoma, tractional retinal folds (with occasional associated detachment), and eventual phtisis bulbi. There have been only a few patients with this condition whose eyes are known to have survived to adulthood. This report describes the clinical and fluorescein angiographic findings of PHPV in an 18-year-old patient. To the best of our knowledge, angiography of the fibrovascular retrolental mass has not been previously reported. The clinical course of this case is unusual in that no catastrophic complication had occurred and no therapeutic intervention was required. The lens resorbed spontaneously, thereby permitting study of the retrolental mass by fluorescein angiography. Fluorescein leakage from the persistent vessels was very slow but present, thus indicating a probable disruption of the endothelial tight junctions of the tunica vasculosa lentis.",
author = "Gieser, {D. K.} and Goldberg, {Morton F} and Apple, {D. J.} and Hamming, {N. A.} and Kottow, {M. H.}",
year = "1978",
language = "English (US)",
volume = "15",
pages = "213--218",
journal = "Journal of Pediatric Ophthalmology and Strabismus",
issn = "0191-3913",
publisher = "Slack Incorporated",
number = "4",

}

TY - JOUR

T1 - Persistent hyperplastic primary vitreous in an adult

T2 - Case report with fluorescein angiographic findings

AU - Gieser, D. K.

AU - Goldberg, Morton F

AU - Apple, D. J.

AU - Hamming, N. A.

AU - Kottow, M. H.

PY - 1978

Y1 - 1978

N2 - Persistent hyperplastic primary vitreous (PHPV) is one of the most serious lesions induced by abnormal development of the embryonic intraocular vasculature. It often progresses to secondary complications such as rupture of the lens capsule and cataract formation, intraocular hemorrhage, secondary glaucoma, tractional retinal folds (with occasional associated detachment), and eventual phtisis bulbi. There have been only a few patients with this condition whose eyes are known to have survived to adulthood. This report describes the clinical and fluorescein angiographic findings of PHPV in an 18-year-old patient. To the best of our knowledge, angiography of the fibrovascular retrolental mass has not been previously reported. The clinical course of this case is unusual in that no catastrophic complication had occurred and no therapeutic intervention was required. The lens resorbed spontaneously, thereby permitting study of the retrolental mass by fluorescein angiography. Fluorescein leakage from the persistent vessels was very slow but present, thus indicating a probable disruption of the endothelial tight junctions of the tunica vasculosa lentis.

AB - Persistent hyperplastic primary vitreous (PHPV) is one of the most serious lesions induced by abnormal development of the embryonic intraocular vasculature. It often progresses to secondary complications such as rupture of the lens capsule and cataract formation, intraocular hemorrhage, secondary glaucoma, tractional retinal folds (with occasional associated detachment), and eventual phtisis bulbi. There have been only a few patients with this condition whose eyes are known to have survived to adulthood. This report describes the clinical and fluorescein angiographic findings of PHPV in an 18-year-old patient. To the best of our knowledge, angiography of the fibrovascular retrolental mass has not been previously reported. The clinical course of this case is unusual in that no catastrophic complication had occurred and no therapeutic intervention was required. The lens resorbed spontaneously, thereby permitting study of the retrolental mass by fluorescein angiography. Fluorescein leakage from the persistent vessels was very slow but present, thus indicating a probable disruption of the endothelial tight junctions of the tunica vasculosa lentis.

UR - http://www.scopus.com/inward/record.url?scp=0017808708&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017808708&partnerID=8YFLogxK

M3 - Article

C2 - 739354

AN - SCOPUS:0017808708

VL - 15

SP - 213

EP - 218

JO - Journal of Pediatric Ophthalmology and Strabismus

JF - Journal of Pediatric Ophthalmology and Strabismus

SN - 0191-3913

IS - 4

ER -