Persistent hippocampal CA1 LTP in mice lacking the C-terminal PDZ ligand of GluR1

Chong Hyun Kim, Kogo Takamiya, Ronald S. Petralia, Rita Sattler, Sandy Yu, Weiguo Zhou, Robert Kalb, Robert Wenthold, Richard Huganir

Research output: Contribution to journalArticle

Abstract

The C-terminal PDZ ligand of the AMPA receptor GluR1 subunit may be important for expression of CA1 hippocampal long-term potentiation. To test this directly in vivo, we generated a knock-in mouse lacking the last seven residues of GluR1, comprising the PDZ ligand. This deletion did not affect basal GluR1 synaptic localization, basal synaptic transmission, long-term potentiation or long-term depression, indicating that the ligand is not required for CA1 hippocampal synaptic plasticity.

Original languageEnglish (US)
Pages (from-to)985-987
Number of pages3
JournalNature neuroscience
Volume8
Issue number8
DOIs
StatePublished - Aug 1 2005

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ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Kim, C. H., Takamiya, K., Petralia, R. S., Sattler, R., Yu, S., Zhou, W., Kalb, R., Wenthold, R., & Huganir, R. (2005). Persistent hippocampal CA1 LTP in mice lacking the C-terminal PDZ ligand of GluR1. Nature neuroscience, 8(8), 985-987. https://doi.org/10.1038/nn1432