Persistent hippocampal CA1 LTP in mice lacking the C-terminal PDZ ligand of GluR1

Chong Hyun Kim; Kogo Takamiya; Ronald S. Petralia; Rita Sattler; Sandy Yu; Weiguo Zhou; Robert Kalb; Robert Wenthold; Richard Huganir

doi:10.1038/nn1432

Persistent hippocampal CA1 LTP in mice lacking the C-terminal PDZ ligand of GluR1

Chong Hyun Kim, Kogo Takamiya, Ronald S. Petralia, Rita Sattler, Sandy Yu, Weiguo Zhou, Robert Kalb, Robert Wenthold, Richard Huganir

School of Medicine

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

Abstract

The C-terminal PDZ ligand of the AMPA receptor GluR1 subunit may be important for expression of CA1 hippocampal long-term potentiation. To test this directly in vivo, we generated a knock-in mouse lacking the last seven residues of GluR1, comprising the PDZ ligand. This deletion did not affect basal GluR1 synaptic localization, basal synaptic transmission, long-term potentiation or long-term depression, indicating that the ligand is not required for CA1 hippocampal synaptic plasticity.

Original language	English (US)
Pages (from-to)	985-987
Number of pages	3
Journal	Nature neuroscience
Volume	8
Issue number	8
DOIs	https://doi.org/10.1038/nn1432
State	Published - Aug 2005

ASJC Scopus subject areas

General Neuroscience

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title = "Persistent hippocampal CA1 LTP in mice lacking the C-terminal PDZ ligand of GluR1",

abstract = "The C-terminal PDZ ligand of the AMPA receptor GluR1 subunit may be important for expression of CA1 hippocampal long-term potentiation. To test this directly in vivo, we generated a knock-in mouse lacking the last seven residues of GluR1, comprising the PDZ ligand. This deletion did not affect basal GluR1 synaptic localization, basal synaptic transmission, long-term potentiation or long-term depression, indicating that the ligand is not required for CA1 hippocampal synaptic plasticity.",

author = "Kim, {Chong Hyun} and Kogo Takamiya and Petralia, {Ronald S.} and Rita Sattler and Sandy Yu and Weiguo Zhou and Robert Kalb and Robert Wenthold and Richard Huganir",

note = "Funding Information: This work was supported by US National Institutes of Health grant NS36715 and the Howard Hughes Medical Institute.",

year = "2005",

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T1 - Persistent hippocampal CA1 LTP in mice lacking the C-terminal PDZ ligand of GluR1

AU - Kim, Chong Hyun

AU - Takamiya, Kogo

AU - Petralia, Ronald S.

AU - Sattler, Rita

AU - Yu, Sandy

AU - Zhou, Weiguo

AU - Kalb, Robert

AU - Wenthold, Robert

AU - Huganir, Richard

N1 - Funding Information: This work was supported by US National Institutes of Health grant NS36715 and the Howard Hughes Medical Institute.

PY - 2005/8

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AB - The C-terminal PDZ ligand of the AMPA receptor GluR1 subunit may be important for expression of CA1 hippocampal long-term potentiation. To test this directly in vivo, we generated a knock-in mouse lacking the last seven residues of GluR1, comprising the PDZ ligand. This deletion did not affect basal GluR1 synaptic localization, basal synaptic transmission, long-term potentiation or long-term depression, indicating that the ligand is not required for CA1 hippocampal synaptic plasticity.

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Persistent hippocampal CA1 LTP in mice lacking the C-terminal PDZ ligand of GluR1

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