Persistent diarrhoea in Zairian AIDS patients: An endoscopic and histological study

R. Colebunders, K. Lusakumuni, Ann Marie Nelson, P. Gigase, I. Lebughe, E. Van Marck, B. Kapita, H. Francis, J. J. Salaun, Thomas C Quinn, P. Piot

Research output: Contribution to journalArticle

Abstract

To determine the aetiology of persistent diarrhoea in African patients with acquired immunodeficiency syndrome (AIDS), 42 patients with human immunodeficiency virus (HIV) and persistent diarrhoea were enrolled in a microbiological, endoscopic, and histological study. Cryptosporidium was the intestinal parasite most often identified (30%); Isospora belli was found in 12% of the patients. Histological examination of the duodenal mucosa showed a non-specific inflammatory reaction in a significantly higher number of HIV-seropositive patients (82%) than HIV-seronegative controls without diarrhoea (52%) (p=0·02). Lymphocytes were more likely to be found in inflammatory reactions in HIV-seropositive patients than in controls (p

Original languageEnglish (US)
Pages (from-to)1687-1691
Number of pages5
JournalGut
Volume29
Issue number12
DOIs
StatePublished - 1988
Externally publishedYes

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Diarrhea
Acquired Immunodeficiency Syndrome
HIV
Isospora
Cryptosporidium
Mucous Membrane
Parasites
Lymphocytes

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Gastroenterology

Cite this

Colebunders, R., Lusakumuni, K., Nelson, A. M., Gigase, P., Lebughe, I., Van Marck, E., ... Piot, P. (1988). Persistent diarrhoea in Zairian AIDS patients: An endoscopic and histological study. Gut, 29(12), 1687-1691. https://doi.org/10.1136/gut.29.12.1687

Persistent diarrhoea in Zairian AIDS patients : An endoscopic and histological study. / Colebunders, R.; Lusakumuni, K.; Nelson, Ann Marie; Gigase, P.; Lebughe, I.; Van Marck, E.; Kapita, B.; Francis, H.; Salaun, J. J.; Quinn, Thomas C; Piot, P.

In: Gut, Vol. 29, No. 12, 1988, p. 1687-1691.

Research output: Contribution to journalArticle

Colebunders, R, Lusakumuni, K, Nelson, AM, Gigase, P, Lebughe, I, Van Marck, E, Kapita, B, Francis, H, Salaun, JJ, Quinn, TC & Piot, P 1988, 'Persistent diarrhoea in Zairian AIDS patients: An endoscopic and histological study', Gut, vol. 29, no. 12, pp. 1687-1691. https://doi.org/10.1136/gut.29.12.1687
Colebunders R, Lusakumuni K, Nelson AM, Gigase P, Lebughe I, Van Marck E et al. Persistent diarrhoea in Zairian AIDS patients: An endoscopic and histological study. Gut. 1988;29(12):1687-1691. https://doi.org/10.1136/gut.29.12.1687
Colebunders, R. ; Lusakumuni, K. ; Nelson, Ann Marie ; Gigase, P. ; Lebughe, I. ; Van Marck, E. ; Kapita, B. ; Francis, H. ; Salaun, J. J. ; Quinn, Thomas C ; Piot, P. / Persistent diarrhoea in Zairian AIDS patients : An endoscopic and histological study. In: Gut. 1988 ; Vol. 29, No. 12. pp. 1687-1691.
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