Persistence of Symptoms After Total vs Supracervical Hysterectomy in Women with Histopathological Diagnosis of Adenomyosis

Mobolaji O. Ajao, Luiz G. Oliveira Brito, Karen Wang, Mary K.B. Cox, Elsemieke Meurs, Emily R. Goggins, Xiangmei Gu, Allison F. Vitonis, Jon I. Einarsson, Sarah L. Cohen

Research output: Contribution to journalArticle

Abstract

Study Objective: To compare symptom persistence in women with adenomyosis based on retention or removal of the cervix at the time of hysterectomy. Design: Retrospective cohort study and follow-up survey (Canadian Task Force classification xx). Setting: Tertiary care academic hospital in Boston, Massachusetts. Patients: Women (n = 1580) who underwent laparoscopic hysterectomy for benign indications between 2008 and 2012 at Brigham and Women's Faulkner Hospital and Brigham and Women's Hospital. Intervention: Retrospective chart review and follow-up survey. Measurements and Main Results: Among the 1580 women contacted, 762 (48%) responded to the postoperative symptom resolution survey. Of these 762 women, 623 agreed to participate in the study. Menopausal women or those who had undergone bilateral salpingo-oophorectomy were excluded. Adenomyosis was identified on histopathologic evaluation of the uterus in 171 of the remaining 443 women (39%). Compared with women without adenomyosis, those with adenomyosis were older on average (mean age, 46.6 ± 6.8 years vs 45.0 ± 5.5 years; p =.009) and more likely to report that abnormal bleeding and pain led to their hysterectomy (87.7% vs 79.8%; p =.03 and 64.9% vs 51.4%; p =.009, respectively). The rates of total and supracervical hysterectomies were similar in the 2 groups. Following surgery, women with adenomyosis were less likely than those without adenomyosis to report persistent pain (adjusted odds ratio [aOR], 0.43; 95% confidence interval [CI], 0.20–0.93; p =.03). Persistent bleeding was similar in the 2 groups (aOR, 0.97; 95% CI, 0.49–1.93; p =.94). Among women with adenomyosis, multivariable logistic regression showed no difference in persistence of symptoms with cervical removal or retention at the time of hysterectomy. Conclusion: Compared with women without adenomyosis, those with histopathologically proven adenomyosis were less likely to report persistent pain following hysterectomy. Retention of the cervix does not appear to increase the risk of symptom persistence or postprocedure patient satisfaction.

Original languageEnglish (US)
JournalJournal of Minimally Invasive Gynecology
DOIs
StateAccepted/In press - Jan 1 2018
Externally publishedYes

Fingerprint

Adenomyosis
Hysterectomy
Pain
Cervix Uteri
Odds Ratio
Confidence Intervals
Hemorrhage
Ovariectomy
Advisory Committees
Tertiary Healthcare
Patient Satisfaction
Uterus

Keywords

  • Adenomyosis
  • Hysterectomy
  • Laparoscopy
  • Supracervical

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Persistence of Symptoms After Total vs Supracervical Hysterectomy in Women with Histopathological Diagnosis of Adenomyosis. / Ajao, Mobolaji O.; Oliveira Brito, Luiz G.; Wang, Karen; Cox, Mary K.B.; Meurs, Elsemieke; Goggins, Emily R.; Gu, Xiangmei; Vitonis, Allison F.; Einarsson, Jon I.; Cohen, Sarah L.

In: Journal of Minimally Invasive Gynecology, 01.01.2018.

Research output: Contribution to journalArticle

Ajao, Mobolaji O. ; Oliveira Brito, Luiz G. ; Wang, Karen ; Cox, Mary K.B. ; Meurs, Elsemieke ; Goggins, Emily R. ; Gu, Xiangmei ; Vitonis, Allison F. ; Einarsson, Jon I. ; Cohen, Sarah L. / Persistence of Symptoms After Total vs Supracervical Hysterectomy in Women with Histopathological Diagnosis of Adenomyosis. In: Journal of Minimally Invasive Gynecology. 2018.
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abstract = "Study Objective: To compare symptom persistence in women with adenomyosis based on retention or removal of the cervix at the time of hysterectomy. Design: Retrospective cohort study and follow-up survey (Canadian Task Force classification xx). Setting: Tertiary care academic hospital in Boston, Massachusetts. Patients: Women (n = 1580) who underwent laparoscopic hysterectomy for benign indications between 2008 and 2012 at Brigham and Women's Faulkner Hospital and Brigham and Women's Hospital. Intervention: Retrospective chart review and follow-up survey. Measurements and Main Results: Among the 1580 women contacted, 762 (48{\%}) responded to the postoperative symptom resolution survey. Of these 762 women, 623 agreed to participate in the study. Menopausal women or those who had undergone bilateral salpingo-oophorectomy were excluded. Adenomyosis was identified on histopathologic evaluation of the uterus in 171 of the remaining 443 women (39{\%}). Compared with women without adenomyosis, those with adenomyosis were older on average (mean age, 46.6 ± 6.8 years vs 45.0 ± 5.5 years; p =.009) and more likely to report that abnormal bleeding and pain led to their hysterectomy (87.7{\%} vs 79.8{\%}; p =.03 and 64.9{\%} vs 51.4{\%}; p =.009, respectively). The rates of total and supracervical hysterectomies were similar in the 2 groups. Following surgery, women with adenomyosis were less likely than those without adenomyosis to report persistent pain (adjusted odds ratio [aOR], 0.43; 95{\%} confidence interval [CI], 0.20–0.93; p =.03). Persistent bleeding was similar in the 2 groups (aOR, 0.97; 95{\%} CI, 0.49–1.93; p =.94). Among women with adenomyosis, multivariable logistic regression showed no difference in persistence of symptoms with cervical removal or retention at the time of hysterectomy. Conclusion: Compared with women without adenomyosis, those with histopathologically proven adenomyosis were less likely to report persistent pain following hysterectomy. Retention of the cervix does not appear to increase the risk of symptom persistence or postprocedure patient satisfaction.",
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AU - Cox, Mary K.B.

AU - Meurs, Elsemieke

AU - Goggins, Emily R.

AU - Gu, Xiangmei

AU - Vitonis, Allison F.

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N2 - Study Objective: To compare symptom persistence in women with adenomyosis based on retention or removal of the cervix at the time of hysterectomy. Design: Retrospective cohort study and follow-up survey (Canadian Task Force classification xx). Setting: Tertiary care academic hospital in Boston, Massachusetts. Patients: Women (n = 1580) who underwent laparoscopic hysterectomy for benign indications between 2008 and 2012 at Brigham and Women's Faulkner Hospital and Brigham and Women's Hospital. Intervention: Retrospective chart review and follow-up survey. Measurements and Main Results: Among the 1580 women contacted, 762 (48%) responded to the postoperative symptom resolution survey. Of these 762 women, 623 agreed to participate in the study. Menopausal women or those who had undergone bilateral salpingo-oophorectomy were excluded. Adenomyosis was identified on histopathologic evaluation of the uterus in 171 of the remaining 443 women (39%). Compared with women without adenomyosis, those with adenomyosis were older on average (mean age, 46.6 ± 6.8 years vs 45.0 ± 5.5 years; p =.009) and more likely to report that abnormal bleeding and pain led to their hysterectomy (87.7% vs 79.8%; p =.03 and 64.9% vs 51.4%; p =.009, respectively). The rates of total and supracervical hysterectomies were similar in the 2 groups. Following surgery, women with adenomyosis were less likely than those without adenomyosis to report persistent pain (adjusted odds ratio [aOR], 0.43; 95% confidence interval [CI], 0.20–0.93; p =.03). Persistent bleeding was similar in the 2 groups (aOR, 0.97; 95% CI, 0.49–1.93; p =.94). Among women with adenomyosis, multivariable logistic regression showed no difference in persistence of symptoms with cervical removal or retention at the time of hysterectomy. Conclusion: Compared with women without adenomyosis, those with histopathologically proven adenomyosis were less likely to report persistent pain following hysterectomy. Retention of the cervix does not appear to increase the risk of symptom persistence or postprocedure patient satisfaction.

AB - Study Objective: To compare symptom persistence in women with adenomyosis based on retention or removal of the cervix at the time of hysterectomy. Design: Retrospective cohort study and follow-up survey (Canadian Task Force classification xx). Setting: Tertiary care academic hospital in Boston, Massachusetts. Patients: Women (n = 1580) who underwent laparoscopic hysterectomy for benign indications between 2008 and 2012 at Brigham and Women's Faulkner Hospital and Brigham and Women's Hospital. Intervention: Retrospective chart review and follow-up survey. Measurements and Main Results: Among the 1580 women contacted, 762 (48%) responded to the postoperative symptom resolution survey. Of these 762 women, 623 agreed to participate in the study. Menopausal women or those who had undergone bilateral salpingo-oophorectomy were excluded. Adenomyosis was identified on histopathologic evaluation of the uterus in 171 of the remaining 443 women (39%). Compared with women without adenomyosis, those with adenomyosis were older on average (mean age, 46.6 ± 6.8 years vs 45.0 ± 5.5 years; p =.009) and more likely to report that abnormal bleeding and pain led to their hysterectomy (87.7% vs 79.8%; p =.03 and 64.9% vs 51.4%; p =.009, respectively). The rates of total and supracervical hysterectomies were similar in the 2 groups. Following surgery, women with adenomyosis were less likely than those without adenomyosis to report persistent pain (adjusted odds ratio [aOR], 0.43; 95% confidence interval [CI], 0.20–0.93; p =.03). Persistent bleeding was similar in the 2 groups (aOR, 0.97; 95% CI, 0.49–1.93; p =.94). Among women with adenomyosis, multivariable logistic regression showed no difference in persistence of symptoms with cervical removal or retention at the time of hysterectomy. Conclusion: Compared with women without adenomyosis, those with histopathologically proven adenomyosis were less likely to report persistent pain following hysterectomy. Retention of the cervix does not appear to increase the risk of symptom persistence or postprocedure patient satisfaction.

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