Persistence of nevirapine exposure during the postpartum period after intrapartum single-dose nevirapine in addition to zidovudine prophylaxis for the prevention of mother-to-child transmission of HIV-1

Tim R. Cressey; Gonzague Jourdain; Marc J. Lallemant; Suparat Kunkeaw; J. Brooks Jackson; Philippa Musoke; Edmund Capparelli; Mark Mirochnick

Persistence of nevirapine exposure during the postpartum period after intrapartum single-dose nevirapine in addition to zidovudine prophylaxis for the prevention of mother-to-child transmission of HIV-1

Tim R. Cressey, Gonzague Jourdain, Marc J. Lallemant, Suparat Kunkeaw, J. Brooks Jackson, Philippa Musoke, Edmund Capparelli, Mark Mirochnick

School of Medicine

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Abstract

Objective: To determine nevirapine (NVP) plasma levels during the postpartum period after a single intrapartum NVP dose for the prevention of mother-to-child transmission. Methods: Plasma samples at delivery and during days 8 to 45 postpartum were obtained from HIV-infected Thai women who received an intrapartum NVP dose in the Perinatal HIV Prevention Clinical Trial-2 (PHPT-2) for the prevention of perinatal HIV transmission. These data were combined with NVP concentration data from 2 phase 1 studies of NVP for a population analysis. Results: The median NVP level fell to 68 ng/mL (range:

Original language	English (US)
Pages (from-to)	283-288
Number of pages	6
Journal	Journal of Acquired Immune Deficiency Syndromes
Volume	38
Issue number	3
State	Published - Mar 1 2005

Keywords

Nevirapine
Pharmacokinetics
Prevention mother-to-child HIV transmission

ASJC Scopus subject areas

Virology
Immunology

Cite this

Cressey, T. R., Jourdain, G., Lallemant, M. J., Kunkeaw, S., Jackson, J. B., Musoke, P., Capparelli, E., & Mirochnick, M. (2005). Persistence of nevirapine exposure during the postpartum period after intrapartum single-dose nevirapine in addition to zidovudine prophylaxis for the prevention of mother-to-child transmission of HIV-1. Journal of Acquired Immune Deficiency Syndromes, 38(3), 283-288.

Persistence of nevirapine exposure during the postpartum period after intrapartum single-dose nevirapine in addition to zidovudine prophylaxis for the prevention of mother-to-child transmission of HIV-1. / Cressey, Tim R.; Jourdain, Gonzague; Lallemant, Marc J. et al.
In: Journal of Acquired Immune Deficiency Syndromes, Vol. 38, No. 3, 01.03.2005, p. 283-288.

Research output: Contribution to journal › Article › peer-review

Cressey, TR, Jourdain, G, Lallemant, MJ, Kunkeaw, S, Jackson, JB, Musoke, P, Capparelli, E & Mirochnick, M 2005, 'Persistence of nevirapine exposure during the postpartum period after intrapartum single-dose nevirapine in addition to zidovudine prophylaxis for the prevention of mother-to-child transmission of HIV-1', Journal of Acquired Immune Deficiency Syndromes, vol. 38, no. 3, pp. 283-288.

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Persistence of nevirapine exposure during the postpartum period after intrapartum single-dose nevirapine in addition to zidovudine prophylaxis for the prevention of mother-to-child transmission of HIV-1

Abstract

Keywords

ASJC Scopus subject areas

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