Perseveration in Alzheimer's disease

S. Pekkala, M. L. Albert, A. Spiro, T. Erkinjuntti

Research output: Contribution to journalArticlepeer-review

Abstract

Background/Aims and Methods: Perseveration is common in Alzheimer's disease (AD). We document the type and quantitative burden of perseveration as cognitive decline progresses from normal aging (n = 30) through mild AD (n = 20) to moderate AD (n = 20) by administering a semantic verbal fluency task. Results: We found perseveration to increase significantly with increasing severity of AD and different types of perseveration that distinguish the subject groups in a statistically significant manner. Recurrent and continuous perseverations appear early in AD. As the disease progresses in severity into moderate stage, the number of recurrent and continuous perseverations increases, and stuck-in-set perseverations emerge. Conclusion: The different types of perseveration are likely to reflect the progressive deterioration of different brain regions in AD.

Original languageEnglish (US)
Pages (from-to)109-114
Number of pages6
JournalDementia and Geriatric Cognitive Disorders
Volume25
Issue number2
DOIs
StatePublished - Feb 2008
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Continuous perseveration
  • Recurrent perseveration
  • Semantic verbal fluency task
  • Stuck-in-set perseveration

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Cognitive Neuroscience
  • Psychiatry and Mental health

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