Peroxynitrite induces destruction of the tetrahydrobiopterin and heme in endothelial nitric oxide synthase: Transition from reversible to irreversible enzyme inhibition

Weiguo Chen, Lawrence J. Druhan, Chun An Chen, Craig Hemann, Yeong Renn Chen, Vladimir Berka, Ah Lim Tsai, Jay L. Zweier

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