Peroxisomal acyl-CoA synthetases

Paul A Watkins, Jessica M. Ellis

Research output: Contribution to journalArticle

Abstract

Peroxisomes carry out many essential lipid metabolic functions. Nearly all of these functions require that an acyl group-either a fatty acid or the acyl side chain of a steroid derivative-be thioesterified to coenzyme A (CoA) for subsequent reactions to proceed. This thioesterification, or "activation", reaction, catalyzed by enzymes belonging to the acyl-CoA synthetase family, is thus central to cellular lipid metabolism. However, despite our rather thorough understanding of peroxisomal metabolic pathways, surprisingly little is known about the specific peroxisomal acyl-CoA synthetases that participate in these pathways. Of the 26 acyl-CoA synthetases encoded by the human and mouse genomes, only a few have been reported to be peroxisomal, including ACSL4, SLC27A2, and SLC27A4. In this review, we briefly describe the primary peroxisomal lipid metabolic pathways in which fatty acyl-CoAs participate. Then, we examine the evidence for presence and functions of acyl-CoA synthetases in peroxisomes, much of which was obtained before the existence of multiple acyl-CoA synthetase isoenzymes was known. Finally, we discuss the role(s) of peroxisome-specific acyl-CoA synthetase isoforms in lipid metabolism. This article is part of a Special Issue entitled: Metabolic Functions and Biogenesis of Peroxisomes in Health and Disease.

Original languageEnglish (US)
Pages (from-to)1411-1420
Number of pages10
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Volume1822
Issue number9
DOIs
StatePublished - Sep 2012

Fingerprint

Coenzyme A Ligases
Peroxisomes
Metabolic Networks and Pathways
Lipid Metabolism
Lipids
Human Genome
Coenzyme A
Isoenzymes
Protein Isoforms
Fatty Acids
Steroids
Health
Enzymes

Keywords

  • Acyl-CoA synthetase
  • Fatty acid activation
  • Lipid metabolism
  • Peroxisome

ASJC Scopus subject areas

  • Molecular Biology
  • Molecular Medicine

Cite this

Peroxisomal acyl-CoA synthetases. / Watkins, Paul A; Ellis, Jessica M.

In: Biochimica et Biophysica Acta - Molecular Basis of Disease, Vol. 1822, No. 9, 09.2012, p. 1411-1420.

Research output: Contribution to journalArticle

Watkins, Paul A ; Ellis, Jessica M. / Peroxisomal acyl-CoA synthetases. In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 2012 ; Vol. 1822, No. 9. pp. 1411-1420.
@article{058bada7645147dc93b5b9e2dce98cdb,
title = "Peroxisomal acyl-CoA synthetases",
abstract = "Peroxisomes carry out many essential lipid metabolic functions. Nearly all of these functions require that an acyl group-either a fatty acid or the acyl side chain of a steroid derivative-be thioesterified to coenzyme A (CoA) for subsequent reactions to proceed. This thioesterification, or {"}activation{"}, reaction, catalyzed by enzymes belonging to the acyl-CoA synthetase family, is thus central to cellular lipid metabolism. However, despite our rather thorough understanding of peroxisomal metabolic pathways, surprisingly little is known about the specific peroxisomal acyl-CoA synthetases that participate in these pathways. Of the 26 acyl-CoA synthetases encoded by the human and mouse genomes, only a few have been reported to be peroxisomal, including ACSL4, SLC27A2, and SLC27A4. In this review, we briefly describe the primary peroxisomal lipid metabolic pathways in which fatty acyl-CoAs participate. Then, we examine the evidence for presence and functions of acyl-CoA synthetases in peroxisomes, much of which was obtained before the existence of multiple acyl-CoA synthetase isoenzymes was known. Finally, we discuss the role(s) of peroxisome-specific acyl-CoA synthetase isoforms in lipid metabolism. This article is part of a Special Issue entitled: Metabolic Functions and Biogenesis of Peroxisomes in Health and Disease.",
keywords = "Acyl-CoA synthetase, Fatty acid activation, Lipid metabolism, Peroxisome",
author = "Watkins, {Paul A} and Ellis, {Jessica M.}",
year = "2012",
month = "9",
doi = "10.1016/j.bbadis.2012.02.010",
language = "English (US)",
volume = "1822",
pages = "1411--1420",
journal = "Biochimica et Biophysica Acta - Molecular Basis of Disease",
issn = "0925-4439",
publisher = "Elsevier",
number = "9",

}

TY - JOUR

T1 - Peroxisomal acyl-CoA synthetases

AU - Watkins, Paul A

AU - Ellis, Jessica M.

PY - 2012/9

Y1 - 2012/9

N2 - Peroxisomes carry out many essential lipid metabolic functions. Nearly all of these functions require that an acyl group-either a fatty acid or the acyl side chain of a steroid derivative-be thioesterified to coenzyme A (CoA) for subsequent reactions to proceed. This thioesterification, or "activation", reaction, catalyzed by enzymes belonging to the acyl-CoA synthetase family, is thus central to cellular lipid metabolism. However, despite our rather thorough understanding of peroxisomal metabolic pathways, surprisingly little is known about the specific peroxisomal acyl-CoA synthetases that participate in these pathways. Of the 26 acyl-CoA synthetases encoded by the human and mouse genomes, only a few have been reported to be peroxisomal, including ACSL4, SLC27A2, and SLC27A4. In this review, we briefly describe the primary peroxisomal lipid metabolic pathways in which fatty acyl-CoAs participate. Then, we examine the evidence for presence and functions of acyl-CoA synthetases in peroxisomes, much of which was obtained before the existence of multiple acyl-CoA synthetase isoenzymes was known. Finally, we discuss the role(s) of peroxisome-specific acyl-CoA synthetase isoforms in lipid metabolism. This article is part of a Special Issue entitled: Metabolic Functions and Biogenesis of Peroxisomes in Health and Disease.

AB - Peroxisomes carry out many essential lipid metabolic functions. Nearly all of these functions require that an acyl group-either a fatty acid or the acyl side chain of a steroid derivative-be thioesterified to coenzyme A (CoA) for subsequent reactions to proceed. This thioesterification, or "activation", reaction, catalyzed by enzymes belonging to the acyl-CoA synthetase family, is thus central to cellular lipid metabolism. However, despite our rather thorough understanding of peroxisomal metabolic pathways, surprisingly little is known about the specific peroxisomal acyl-CoA synthetases that participate in these pathways. Of the 26 acyl-CoA synthetases encoded by the human and mouse genomes, only a few have been reported to be peroxisomal, including ACSL4, SLC27A2, and SLC27A4. In this review, we briefly describe the primary peroxisomal lipid metabolic pathways in which fatty acyl-CoAs participate. Then, we examine the evidence for presence and functions of acyl-CoA synthetases in peroxisomes, much of which was obtained before the existence of multiple acyl-CoA synthetase isoenzymes was known. Finally, we discuss the role(s) of peroxisome-specific acyl-CoA synthetase isoforms in lipid metabolism. This article is part of a Special Issue entitled: Metabolic Functions and Biogenesis of Peroxisomes in Health and Disease.

KW - Acyl-CoA synthetase

KW - Fatty acid activation

KW - Lipid metabolism

KW - Peroxisome

UR - http://www.scopus.com/inward/record.url?scp=84864052316&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84864052316&partnerID=8YFLogxK

U2 - 10.1016/j.bbadis.2012.02.010

DO - 10.1016/j.bbadis.2012.02.010

M3 - Article

C2 - 22366061

AN - SCOPUS:84864052316

VL - 1822

SP - 1411

EP - 1420

JO - Biochimica et Biophysica Acta - Molecular Basis of Disease

JF - Biochimica et Biophysica Acta - Molecular Basis of Disease

SN - 0925-4439

IS - 9

ER -