Peropsin, a novel visual pigment-like protein located in the apical microvilli of the retinal pigment epithelium

Hui Sun, Debra J. Gilbert, Neal G. Copeland, Nancy A. Jenkins, Jeremy Nathans

Research output: Contribution to journalArticle

Abstract

A visual pigment-like protein, referred to as peropsin, has been identified by large-scale sequencing of cDNAs derived from human ocular tissues. The corresponding mRNA was found only in the eye, where it is localized to the retinal pigment epithelium (RPE). Peropsin immunoreactivity, visualized by light and electron microscopy, localizes the protein to the apical face of the RPE, and most prominently to the microvilli that surround the photoreceptor outer segments. These observations suggest that peropsin may play a role in RPE physiology either by detecting light directly or by monitoring the concentration of retinoids or other photoreceptor-derived compounds.

Original languageEnglish (US)
Pages (from-to)9893-9898
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume94
Issue number18
DOIs
StatePublished - Sep 2 1997

ASJC Scopus subject areas

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