“Permissive AKI” with treatment of heart failure

Chirag R. Parikh, Steven G. Coca

Research output: Contribution to journalComment/debate


Renin–angiotensin–aldosterone system inhibitors have proven clinical benefit in management of patients with heart failure with reduced ejection fraction. However, there are no guidelines to manage decline in kidney function that occurs with initiation and titration of renin–angiotensin–aldosterone system agents during management of heart failure. We discuss the complex interplay of kidney function and heart failure in the presence of renin–angiotensin–aldosterone system agents and suggest a clinical algorithm for management of acute decline in kidney function.

Original languageEnglish (US)
Pages (from-to)1066-1068
Number of pages3
JournalKidney International
Issue number5
Publication statusPublished - Nov 2019


ASJC Scopus subject areas

  • Nephrology

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