Perivenular brain lesions in a primate multiple sclerosis model at 7-tesla magnetic resonance imaging

María I. Gaitán, Pietro Maggi, Jillian Wohler, Emily Leibovitch, Pascal Sati, Ismael L. Calandri, Hellmut Merkle, Luca Massacesi, Afonso C. Silva, Steven Jacobson, Daniel S. Reich

Research output: Contribution to journalArticle

Abstract

Background. Magnetic resonance imaging (MRI) can provide in vivo assessment of tissue damage, allowing evaluation of multiple sclerosis (MS) lesion evolution over time - a perspective not obtainable with postmortem histopathology. Relapsing-remitting experimental autoimmune encephalomyelitis (EAE) is an experimental model of MS that can be induced in the common marmoset, a small new world primate, and that causes perivenular white matter (WM) lesions similar to those observed in MS. Methods. Brain lesion development and evolution were studied in vivo and postmortem in four marmosets with EAE through serial T2- and T2-weighted scans at 7-tesla. Supratentorial WM lesions were identified and characterized. Results. Of 97 lesions observed, 86 (88%) were clearly perivenular, and 62 (72%) developed around veins that were visible even prior to EAE induction. The perivenular configuration was confirmed by postmortem histopathology. Most affected veins, and their related perivascular Virchow-Robin spaces, passed into the subarachnoid space rather than the ventricles. Conclusion. As in human MS, the intimate association between small veins and EAE lesions in the marmoset can be studied with serial in vivo MRI. This further strengthens the usefulness of this model for understanding the process of perivenular lesion development and accompanying tissue destruction in MS.

Original languageEnglish (US)
Pages (from-to)64-71
Number of pages8
JournalMultiple Sclerosis
Volume20
Issue number1
DOIs
StatePublished - Jan 1 2014

Keywords

  • Veins
  • experimental autoimmune encephalomyelitis
  • magnetic resonance imaging
  • multiple sclerosis
  • susceptibility weighted imaging

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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  • Cite this

    Gaitán, M. I., Maggi, P., Wohler, J., Leibovitch, E., Sati, P., Calandri, I. L., Merkle, H., Massacesi, L., Silva, A. C., Jacobson, S., & Reich, D. S. (2014). Perivenular brain lesions in a primate multiple sclerosis model at 7-tesla magnetic resonance imaging. Multiple Sclerosis, 20(1), 64-71. https://doi.org/10.1177/1352458513492244