Perivascular Mesenchymal Progenitors for Bone Regeneration

Aaron W. James, Bruno Péault

Research output: Contribution to journalReview articlepeer-review

Abstract

Mesenchymal progenitor cells reside in all assayed vascularized tissues, and are broadly conceptualized to participate in homeostasis/renewal and repair. The application of mesenchymal progenitor cells has been studied for diverse orthopaedic conditions related to skeletal degeneration, regeneration, and tissue fabrication. One common niche for mesenchymal progenitors is the perivascular space, and in both mouse and human tissues, perivascular progenitor cells have been isolated and characterized. Of these “perivascular stem cells” or PSC, pericytes are the most commonly studied cells. Multiple studies have demonstrated the regenerative properties of PSC when applied to bone, including direct osteochondral differentiation, paracrine-induced osteogenesis and vasculogenesis, and immunomodulatory functions. The confluence of these effects have resulted in efficacious bone regeneration across several preclinical models. Yet, key topics of research in perivascular progenitors highlight our lack of knowledge regarding these cell populations. These ongoing areas of study include cellular diversity within the perivascular niche, tissue-specific properties of PSC, and factors that influence PSC-mediated regenerative potential.

Original languageEnglish (US)
Pages (from-to)1221-1228
Number of pages8
JournalJournal of Orthopaedic Research
Volume37
Issue number6
DOIs
StatePublished - Jun 2019

Keywords

  • bone repair
  • bone tissue engineering
  • mesenchymal stem cell
  • mesenchymal stromal cell
  • pericyte
  • perivascular stem cell
  • perivascular stromal cell

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

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