Peritrophic matrix proteins of Anopheles gambiae and Aedes aegypti

L. A. Moskalyk, M. M. Oo, Marcelo Jacobs-Lorena

Research output: Contribution to journalArticle

Abstract

Little is known about the composition and function of the mosquito peritrophic matrix (PM), a physical barrier that pathogens must traverse to complete their life cycles. Anopheles gambiae and Aedes aegypti PM proteins induced by blood or by a protein-free meal have been characterized by the use of 2-D gel electrophoresis and lectin-binding affinity assays. More than forty proteins have been identified in both species. Over half of the PM proteins of both mosquitoes migrate identically. Many PM proteins appear to be glycosylated, primarily by high mannose N-linked glycosyl groups.

Original languageEnglish (US)
Pages (from-to)261-268
Number of pages8
JournalInsect Molecular Biology
Volume5
Issue number4
StatePublished - Nov 1996
Externally publishedYes

Fingerprint

Anopheles gambiae
peritrophic membrane
Aedes
Aedes aegypti
Culicidae
Proteins
proteins
Architectural Accessibility
Electrophoresis, Gel, Two-Dimensional
Mannose
Life Cycle Stages
Lectins
Meals
Blood Proteins
Pathogens
Electrophoresis
mannose
lectins
gel electrophoresis
Life cycle

Keywords

  • 2-D gels
  • Aedes
  • Anopheles
  • lectins
  • peritrophic matrix

ASJC Scopus subject areas

  • Insect Science
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry

Cite this

Peritrophic matrix proteins of Anopheles gambiae and Aedes aegypti. / Moskalyk, L. A.; Oo, M. M.; Jacobs-Lorena, Marcelo.

In: Insect Molecular Biology, Vol. 5, No. 4, 11.1996, p. 261-268.

Research output: Contribution to journalArticle

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