Peritoneal involvement in stage II colon cancer

Anne Marie O'Broin-Lennon, H. E. Mulcahy, J. M P Hyland, C. Lowry, A. White, D. Fennelly, J. J. Murphy, D. P. O'Donoghue, K. Sheahan

Research output: Contribution to journalArticlepeer-review

Abstract

A pathologist (K.S.) reviewed histologic slides for peritoneal involvement by tumor cells for 118 patients with stage II colon cancer. Patients were followed up for a median of 6 years. Tumor cells were found free in the peritoneal space in 16 cases (13.6%). The presence of cancer cells free in the peritoneal space was associated with lymphovascular invasion (P = .001) and neural invasion (P <.001). The overall 5-year survival was 80% in the patient population, but was 39% and 86% for those with and without tumor cells free in the peritoneal space, respectively (P <.0001). Multivariate analysis confirmed that free tumor cells within the peritoneal space (P <.0001) and lymphovascular invasion (P = .007) were related independently to outcome. Peritoneal involvement with tumor cells free in the peritoneal space in stage II colon cancer is a powerful indicator of outcome; patients have a survival similar to that for patients with stage III disease.

Original languageEnglish (US)
Pages (from-to)108-113
Number of pages6
JournalAmerican Journal of Clinical Pathology
Volume119
Issue number1
DOIs
StatePublished - Jan 1 2003
Externally publishedYes

Keywords

  • Clinicopathologic staging
  • Colorectal cancer
  • Dukes B
  • Local peritoneal involvement
  • Lymph node-negative
  • Peritoneum
  • Prognosis
  • Stage II
  • Survival
  • T4
  • TNM

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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