Peritoneal involvement in stage II colon cancer

Anne Marie O'Broin-Lennon; H. E. Mulcahy; J. M P Hyland; C. Lowry; A. White; D. Fennelly; J. J. Murphy; D. P. O'Donoghue; K. Sheahan

doi:10.1309/J6BD-TWM2-M792-TN2V

Peritoneal involvement in stage II colon cancer

Anne Marie O'Broin-Lennon, H. E. Mulcahy, J. M P Hyland, C. Lowry, A. White, D. Fennelly, J. J. Murphy, D. P. O'Donoghue, K. Sheahan

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

A pathologist (K.S.) reviewed histologic slides for peritoneal involvement by tumor cells for 118 patients with stage II colon cancer. Patients were followed up for a median of 6 years. Tumor cells were found free in the peritoneal space in 16 cases (13.6%). The presence of cancer cells free in the peritoneal space was associated with lymphovascular invasion (P = .001) and neural invasion (P <.001). The overall 5-year survival was 80% in the patient population, but was 39% and 86% for those with and without tumor cells free in the peritoneal space, respectively (P <.0001). Multivariate analysis confirmed that free tumor cells within the peritoneal space (P <.0001) and lymphovascular invasion (P = .007) were related independently to outcome. Peritoneal involvement with tumor cells free in the peritoneal space in stage II colon cancer is a powerful indicator of outcome; patients have a survival similar to that for patients with stage III disease.

Original language	English (US)
Pages (from-to)	108-113
Number of pages	6
Journal	American Journal of Clinical Pathology
Volume	119
Issue number	1
DOIs	https://doi.org/10.1309/J6BD-TWM2-M792-TN2V
State	Published - Jan 1 2003
Externally published	Yes

Keywords

Clinicopathologic staging
Colorectal cancer
Dukes B
Local peritoneal involvement
Lymph node-negative
Peritoneum
Prognosis
Stage II
Survival
T4
TNM

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1309/J6BD-TWM2-M792-TN2V

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title = "Peritoneal involvement in stage II colon cancer",

abstract = "A pathologist (K.S.) reviewed histologic slides for peritoneal involvement by tumor cells for 118 patients with stage II colon cancer. Patients were followed up for a median of 6 years. Tumor cells were found free in the peritoneal space in 16 cases (13.6%). The presence of cancer cells free in the peritoneal space was associated with lymphovascular invasion (P = .001) and neural invasion (P <.001). The overall 5-year survival was 80% in the patient population, but was 39% and 86% for those with and without tumor cells free in the peritoneal space, respectively (P <.0001). Multivariate analysis confirmed that free tumor cells within the peritoneal space (P <.0001) and lymphovascular invasion (P = .007) were related independently to outcome. Peritoneal involvement with tumor cells free in the peritoneal space in stage II colon cancer is a powerful indicator of outcome; patients have a survival similar to that for patients with stage III disease.",

keywords = "Clinicopathologic staging, Colorectal cancer, Dukes B, Local peritoneal involvement, Lymph node-negative, Peritoneum, Prognosis, Stage II, Survival, T4, TNM",

author = "O'Broin-Lennon, {Anne Marie} and Mulcahy, {H. E.} and Hyland, {J. M P} and C. Lowry and A. White and D. Fennelly and Murphy, {J. J.} and O'Donoghue, {D. P.} and K. Sheahan",

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doi = "10.1309/J6BD-TWM2-M792-TN2V",

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AU - O'Broin-Lennon, Anne Marie

AU - Mulcahy, H. E.

AU - Hyland, J. M P

AU - Lowry, C.

AU - White, A.

AU - Fennelly, D.

AU - Murphy, J. J.

AU - O'Donoghue, D. P.

AU - Sheahan, K.

PY - 2003/1/1

Y1 - 2003/1/1

N2 - A pathologist (K.S.) reviewed histologic slides for peritoneal involvement by tumor cells for 118 patients with stage II colon cancer. Patients were followed up for a median of 6 years. Tumor cells were found free in the peritoneal space in 16 cases (13.6%). The presence of cancer cells free in the peritoneal space was associated with lymphovascular invasion (P = .001) and neural invasion (P <.001). The overall 5-year survival was 80% in the patient population, but was 39% and 86% for those with and without tumor cells free in the peritoneal space, respectively (P <.0001). Multivariate analysis confirmed that free tumor cells within the peritoneal space (P <.0001) and lymphovascular invasion (P = .007) were related independently to outcome. Peritoneal involvement with tumor cells free in the peritoneal space in stage II colon cancer is a powerful indicator of outcome; patients have a survival similar to that for patients with stage III disease.

AB - A pathologist (K.S.) reviewed histologic slides for peritoneal involvement by tumor cells for 118 patients with stage II colon cancer. Patients were followed up for a median of 6 years. Tumor cells were found free in the peritoneal space in 16 cases (13.6%). The presence of cancer cells free in the peritoneal space was associated with lymphovascular invasion (P = .001) and neural invasion (P <.001). The overall 5-year survival was 80% in the patient population, but was 39% and 86% for those with and without tumor cells free in the peritoneal space, respectively (P <.0001). Multivariate analysis confirmed that free tumor cells within the peritoneal space (P <.0001) and lymphovascular invasion (P = .007) were related independently to outcome. Peritoneal involvement with tumor cells free in the peritoneal space in stage II colon cancer is a powerful indicator of outcome; patients have a survival similar to that for patients with stage III disease.

KW - Clinicopathologic staging

KW - Colorectal cancer

KW - Dukes B

KW - Local peritoneal involvement

KW - Lymph node-negative

KW - Peritoneum

KW - Prognosis

KW - Stage II

KW - Survival

KW - T4

KW - TNM

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EP - 113

JO - American Journal of Clinical Pathology

JF - American Journal of Clinical Pathology

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Peritoneal involvement in stage II colon cancer

Abstract

Keywords

ASJC Scopus subject areas

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