Peripheral nerve injury up-regulates expression of interactor protein for cytohesin exchange factor 1 (IPCEF1) mRNA in rat dorsal root ganglion

Xiaowei Guan; Xuguang Zhu; Yuan Xiang Tao

doi:10.1007/s00210-009-0451-7

Peripheral nerve injury up-regulates expression of interactor protein for cytohesin exchange factor 1 (IPCEF1) mRNA in rat dorsal root ganglion

Xiaowei Guan, Xuguang Zhu, Yuan Xiang Tao

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Interaction protein for cytohesin exchange factors 1 (IPCEF1) is a recently identified protein that binds to cytohesin 2 and might participate in membrane receptor trafficking by enhancing the activity of cytohesin 2 in cultured cells. However, whether IPCEF1 is involved in this process in vivo is unknown. Here, we report that IPCEF1 messenger RNA (mRNA) is expressed in the dorsal root ganglions (DRGs) of adult rats. Moreover, peripheral nerve injury induced by fifth spinal nerve ligation and transection or sciatic nerve transection significantly up-regulated expression of IPCEF1 mRNA in the injured DRGs. Because peripheral nerve injury leads to changes in membrane receptor trafficking in the injured DRG, the correlation of IPCEF1 mRNA expression with nerve injury input in the injured DRG suggests that IPCEF1 might participate in the mechanisms that underlie nerve injury-induced membrane receptor trafficking in the DRG under neuropathic pain conditions.

Original language	English (US)
Pages (from-to)	459-463
Number of pages	5
Journal	Naunyn-Schmiedeberg's Archives of Pharmacology
Volume	380
Issue number	5
DOIs	https://doi.org/10.1007/s00210-009-0451-7
State	Published - Nov 2009
Externally published	Yes

Keywords

Dorsal root ganglion
Interaction protein for cytohesin exchange factors 1
Neuropathic pain

ASJC Scopus subject areas

Pharmacology

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10.1007/s00210-009-0451-7

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title = "Peripheral nerve injury up-regulates expression of interactor protein for cytohesin exchange factor 1 (IPCEF1) mRNA in rat dorsal root ganglion",

abstract = "Interaction protein for cytohesin exchange factors 1 (IPCEF1) is a recently identified protein that binds to cytohesin 2 and might participate in membrane receptor trafficking by enhancing the activity of cytohesin 2 in cultured cells. However, whether IPCEF1 is involved in this process in vivo is unknown. Here, we report that IPCEF1 messenger RNA (mRNA) is expressed in the dorsal root ganglions (DRGs) of adult rats. Moreover, peripheral nerve injury induced by fifth spinal nerve ligation and transection or sciatic nerve transection significantly up-regulated expression of IPCEF1 mRNA in the injured DRGs. Because peripheral nerve injury leads to changes in membrane receptor trafficking in the injured DRG, the correlation of IPCEF1 mRNA expression with nerve injury input in the injured DRG suggests that IPCEF1 might participate in the mechanisms that underlie nerve injury-induced membrane receptor trafficking in the DRG under neuropathic pain conditions.",

keywords = "Dorsal root ganglion, Interaction protein for cytohesin exchange factors 1, Neuropathic pain",

author = "Xiaowei Guan and Xuguang Zhu and Tao, {Yuan Xiang}",

note = "Funding Information: Acknowledgements This work was supported by National Institutes of Health Grants NS 058886 and NS 057343, and Johns Hopkins University Blaustein Pain Research Fund (Y.-X. T). The authors thank Claire Levine, MS, for her editorial assistance.",

year = "2009",

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doi = "10.1007/s00210-009-0451-7",

language = "English (US)",

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AU - Guan, Xiaowei

AU - Zhu, Xuguang

AU - Tao, Yuan Xiang

N1 - Funding Information: Acknowledgements This work was supported by National Institutes of Health Grants NS 058886 and NS 057343, and Johns Hopkins University Blaustein Pain Research Fund (Y.-X. T). The authors thank Claire Levine, MS, for her editorial assistance.

PY - 2009/11

Y1 - 2009/11

N2 - Interaction protein for cytohesin exchange factors 1 (IPCEF1) is a recently identified protein that binds to cytohesin 2 and might participate in membrane receptor trafficking by enhancing the activity of cytohesin 2 in cultured cells. However, whether IPCEF1 is involved in this process in vivo is unknown. Here, we report that IPCEF1 messenger RNA (mRNA) is expressed in the dorsal root ganglions (DRGs) of adult rats. Moreover, peripheral nerve injury induced by fifth spinal nerve ligation and transection or sciatic nerve transection significantly up-regulated expression of IPCEF1 mRNA in the injured DRGs. Because peripheral nerve injury leads to changes in membrane receptor trafficking in the injured DRG, the correlation of IPCEF1 mRNA expression with nerve injury input in the injured DRG suggests that IPCEF1 might participate in the mechanisms that underlie nerve injury-induced membrane receptor trafficking in the DRG under neuropathic pain conditions.

AB - Interaction protein for cytohesin exchange factors 1 (IPCEF1) is a recently identified protein that binds to cytohesin 2 and might participate in membrane receptor trafficking by enhancing the activity of cytohesin 2 in cultured cells. However, whether IPCEF1 is involved in this process in vivo is unknown. Here, we report that IPCEF1 messenger RNA (mRNA) is expressed in the dorsal root ganglions (DRGs) of adult rats. Moreover, peripheral nerve injury induced by fifth spinal nerve ligation and transection or sciatic nerve transection significantly up-regulated expression of IPCEF1 mRNA in the injured DRGs. Because peripheral nerve injury leads to changes in membrane receptor trafficking in the injured DRG, the correlation of IPCEF1 mRNA expression with nerve injury input in the injured DRG suggests that IPCEF1 might participate in the mechanisms that underlie nerve injury-induced membrane receptor trafficking in the DRG under neuropathic pain conditions.

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KW - Interaction protein for cytohesin exchange factors 1

KW - Neuropathic pain

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Peripheral nerve injury up-regulates expression of interactor protein for cytohesin exchange factor 1 (IPCEF1) mRNA in rat dorsal root ganglion

Abstract

Keywords

ASJC Scopus subject areas

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