Peripheral nerve grafts exert trophic and tropic effects on anterior thalamic neurons

Richard E. Clatterbuck, Donald L. Price, Vassilis El Koliatsos

Research output: Contribution to journalArticle

Abstract

Peripheral nerve grafting into the central nervous system (CNS) has been used to study the regenerative capabilities of central neurons given access to a peripheral nervous system (PNS) environment. It is well documented that many CNS neurons regenerate axons along peripheral nerve grafts placed in close proximity to their cell bodies and that these grafts can ameliorate axotomy-induced retrograde degeneration. In the present study, we placed peripheral nerve grafts in proximity to axotomized neurons of the anterior thalamus. Standard histological and retrograde tracing techniques were used to examine these preparations 2 months after grafting. Three effects of these grafts were observed: amelioration of retrograde degeneration of axotomized anterior thalamic neurons, hypertrophy of many thalamic neurons in the local environment of the graft, and ingrowth of axons of axotomized anterior thalamic neurons as well as nonaxotomized neurons from surrounding nuclei. We conclude from these studies that peripheral nerve grafts not only provide a matrix for axonal outgrowth but also exert marked trophic and tropic effects on axotomized anterior thalamic neurons.

Original languageEnglish (US)
Pages (from-to)17-26
Number of pages10
JournalNeurobiology of Disease
Volume5
Issue number1
DOIs
StatePublished - Jul 1998

Fingerprint

Peripheral Nerves
Transplants
Neurons
Retrograde Degeneration
Axons
Central Nervous System
Anterior Thalamic Nuclei
Axotomy
Peripheral Nervous System
Hypertrophy

Keywords

  • Axotomy
  • Central nervous system
  • Degeneration
  • Regeneration
  • Trophic factors

ASJC Scopus subject areas

  • Neurology

Cite this

Peripheral nerve grafts exert trophic and tropic effects on anterior thalamic neurons. / Clatterbuck, Richard E.; Price, Donald L.; Koliatsos, Vassilis El.

In: Neurobiology of Disease, Vol. 5, No. 1, 07.1998, p. 17-26.

Research output: Contribution to journalArticle

@article{e5632f67782c4e689e7db2758de8f5d5,
title = "Peripheral nerve grafts exert trophic and tropic effects on anterior thalamic neurons",
abstract = "Peripheral nerve grafting into the central nervous system (CNS) has been used to study the regenerative capabilities of central neurons given access to a peripheral nervous system (PNS) environment. It is well documented that many CNS neurons regenerate axons along peripheral nerve grafts placed in close proximity to their cell bodies and that these grafts can ameliorate axotomy-induced retrograde degeneration. In the present study, we placed peripheral nerve grafts in proximity to axotomized neurons of the anterior thalamus. Standard histological and retrograde tracing techniques were used to examine these preparations 2 months after grafting. Three effects of these grafts were observed: amelioration of retrograde degeneration of axotomized anterior thalamic neurons, hypertrophy of many thalamic neurons in the local environment of the graft, and ingrowth of axons of axotomized anterior thalamic neurons as well as nonaxotomized neurons from surrounding nuclei. We conclude from these studies that peripheral nerve grafts not only provide a matrix for axonal outgrowth but also exert marked trophic and tropic effects on axotomized anterior thalamic neurons.",
keywords = "Axotomy, Central nervous system, Degeneration, Regeneration, Trophic factors",
author = "Clatterbuck, {Richard E.} and Price, {Donald L.} and Koliatsos, {Vassilis El}",
year = "1998",
month = "7",
doi = "10.1006/nbdi.1998.0181",
language = "English (US)",
volume = "5",
pages = "17--26",
journal = "Neurobiology of Disease",
issn = "0969-9961",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Peripheral nerve grafts exert trophic and tropic effects on anterior thalamic neurons

AU - Clatterbuck, Richard E.

AU - Price, Donald L.

AU - Koliatsos, Vassilis El

PY - 1998/7

Y1 - 1998/7

N2 - Peripheral nerve grafting into the central nervous system (CNS) has been used to study the regenerative capabilities of central neurons given access to a peripheral nervous system (PNS) environment. It is well documented that many CNS neurons regenerate axons along peripheral nerve grafts placed in close proximity to their cell bodies and that these grafts can ameliorate axotomy-induced retrograde degeneration. In the present study, we placed peripheral nerve grafts in proximity to axotomized neurons of the anterior thalamus. Standard histological and retrograde tracing techniques were used to examine these preparations 2 months after grafting. Three effects of these grafts were observed: amelioration of retrograde degeneration of axotomized anterior thalamic neurons, hypertrophy of many thalamic neurons in the local environment of the graft, and ingrowth of axons of axotomized anterior thalamic neurons as well as nonaxotomized neurons from surrounding nuclei. We conclude from these studies that peripheral nerve grafts not only provide a matrix for axonal outgrowth but also exert marked trophic and tropic effects on axotomized anterior thalamic neurons.

AB - Peripheral nerve grafting into the central nervous system (CNS) has been used to study the regenerative capabilities of central neurons given access to a peripheral nervous system (PNS) environment. It is well documented that many CNS neurons regenerate axons along peripheral nerve grafts placed in close proximity to their cell bodies and that these grafts can ameliorate axotomy-induced retrograde degeneration. In the present study, we placed peripheral nerve grafts in proximity to axotomized neurons of the anterior thalamus. Standard histological and retrograde tracing techniques were used to examine these preparations 2 months after grafting. Three effects of these grafts were observed: amelioration of retrograde degeneration of axotomized anterior thalamic neurons, hypertrophy of many thalamic neurons in the local environment of the graft, and ingrowth of axons of axotomized anterior thalamic neurons as well as nonaxotomized neurons from surrounding nuclei. We conclude from these studies that peripheral nerve grafts not only provide a matrix for axonal outgrowth but also exert marked trophic and tropic effects on axotomized anterior thalamic neurons.

KW - Axotomy

KW - Central nervous system

KW - Degeneration

KW - Regeneration

KW - Trophic factors

UR - http://www.scopus.com/inward/record.url?scp=0032126432&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032126432&partnerID=8YFLogxK

U2 - 10.1006/nbdi.1998.0181

DO - 10.1006/nbdi.1998.0181

M3 - Article

VL - 5

SP - 17

EP - 26

JO - Neurobiology of Disease

JF - Neurobiology of Disease

SN - 0969-9961

IS - 1

ER -