Peripheral blood gene expression profiling for cardiovascular disease assessment

Hamza Aziz, Aimee Zaas, Geoffrey S. Ginsburg

Research output: Contribution to journalReview articlepeer-review

Abstract

Whole blood gene expression profiling has the potential to be informative about dynamic changes in disease states and to provide information on underlying disease mechanisms. Having demonstrated proof of concept in animal models, a number of studies have now tried to tackle the complexity of cardiovascular disease in human hosts to develop better diagnostic and prognostic indicators. These studies show that genomic signatures are capable of classifying patients with cardiovascular diseases into finer categories based on the molecular architecture of a patient's disease and more accurately predict the likelihood of a cardiovascular event than current techniques. To highlight the spectrum of potential applications of whole blood gene expression profiling approach in cardiovascular science, we have chosen to review the findings in a number of complex cardiovascular diseases such as atherosclerosis, hypertension and myocardial infarction as well as thromboembolism, aortic aneurysm, and heart transplant.

Original languageEnglish (US)
Pages (from-to)105-112
Number of pages8
JournalGenomic Medicine
Volume1
Issue number3-4
DOIs
StatePublished - Sep 2007
Externally publishedYes

Keywords

  • Cardiovascular
  • Genomic techniques
  • Microarray analysis
  • Whole blood gene expression profiling

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Fingerprint Dive into the research topics of 'Peripheral blood gene expression profiling for cardiovascular disease assessment'. Together they form a unique fingerprint.

Cite this