TY - JOUR
T1 - Peripheral blood count abnormalities among patients with hepatitis C in the United States
AU - Streiff, Michael B.
AU - Mehta, Shruti
AU - Thomas, David L.
N1 - Funding Information:
Abbreviations: HCV, hepatitis C virus; NHANES III, Third National Health and Nutrition Examination Survey; anti-HCV, HCV antibody; BMI, body mass index. From the 1Department of Medicine, Johns Hopkins University School of Medicine; and the 2Department of Epidemiology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD. Received September 14, 2001; accepted January 21, 2002. Supported by the National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Disease (DA 10627). Address reprint requests to: David L. Thomas, M.D., M.P.H., Associate Professor of Medicine, 424 N. Bond St., Baltimore, MD 21231. E-mail: dthomas@jhmi.edu; fax: 410-614-7564. Copyright © 2002 by the American Association for the Study of Liver Diseases. 0270-9139/02/3504-0027$35.00/0 doi:10.1053/jhep.2002.32486
PY - 2002
Y1 - 2002
N2 - An estimated 2.7 million people in the United States are infected with the hepatitis C virus (HCV), yet the influence of HCV infection on the peripheral blood count remains unknown. To investigate the prevalence of low peripheral blood counts among HCV-infected adults in the United States general population, we analyzed data collected in the third National Health and Nutrition Examination Survey (NHANES III). The study population consisted of 16,196 individuals age 18 or older who had peripheral blood counts and data on HCV infection. The lowest fifth percentile of each component of the peripheral blood was designated a priori as being low. HCV infection was assessed by antibody reactivity. HCV antibody-positive individuals were 3-fold more likely to have low neutrophil counts (HCV positive, 9% vs. HCV negative, 3%, P < .0001) and 2.6-fold more likely to have low platelet counts (HCV positive, 13% vs. HCV negative, 5%, P < .0001) independent of other evaluated factors. HCV infection was observed in more than 20% of persons with neutrophil counts below 1.0 × 109/L or platelet counts less than 100 × 109/L. No association was detected between anti-HCV status and anemia or other peripheral blood cell components. In conclusion, HCV-infected persons in the general population of the United States are more likely to have low neutrophil and platelet counts, and HCV testing should be considered for persons with unexplained neutrophil counts below 1.0 × 109/L or platelet counts less than 100 × 109/L. Alternate causes of anemia should be considered for HCV-infected persons with low red blood cell counts.
AB - An estimated 2.7 million people in the United States are infected with the hepatitis C virus (HCV), yet the influence of HCV infection on the peripheral blood count remains unknown. To investigate the prevalence of low peripheral blood counts among HCV-infected adults in the United States general population, we analyzed data collected in the third National Health and Nutrition Examination Survey (NHANES III). The study population consisted of 16,196 individuals age 18 or older who had peripheral blood counts and data on HCV infection. The lowest fifth percentile of each component of the peripheral blood was designated a priori as being low. HCV infection was assessed by antibody reactivity. HCV antibody-positive individuals were 3-fold more likely to have low neutrophil counts (HCV positive, 9% vs. HCV negative, 3%, P < .0001) and 2.6-fold more likely to have low platelet counts (HCV positive, 13% vs. HCV negative, 5%, P < .0001) independent of other evaluated factors. HCV infection was observed in more than 20% of persons with neutrophil counts below 1.0 × 109/L or platelet counts less than 100 × 109/L. No association was detected between anti-HCV status and anemia or other peripheral blood cell components. In conclusion, HCV-infected persons in the general population of the United States are more likely to have low neutrophil and platelet counts, and HCV testing should be considered for persons with unexplained neutrophil counts below 1.0 × 109/L or platelet counts less than 100 × 109/L. Alternate causes of anemia should be considered for HCV-infected persons with low red blood cell counts.
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U2 - 10.1053/jhep.2002.32486
DO - 10.1053/jhep.2002.32486
M3 - Article
C2 - 11915043
AN - SCOPUS:0036205713
SN - 0270-9139
VL - 35
SP - 947
EP - 952
JO - Hepatology
JF - Hepatology
IS - 4
ER -