Peripheral blood allogeneic microchimerism in lung and cardiac allograft recipients

Nancy L. Reinsmoen, Annette Jackson, Marshall Hertz, Kay Savik, Spencer Kubo, Sophia Ormaza, Leslie Miller, Cynthia McSherry

Research output: Contribution to journalArticle

Abstract

We have been investigating two parameters, donor antigen-specific hyporeactivity and peripheral blood allogeneic microchimerism, to determine whether these parameters will predict a chronic rejection-free state and which recipients may be candidates for steroid withdrawal. We have identified donor antigen-specific hyporeactivity for 33% (16/48) of lung and 23% (11/47) of heart recipients. For both organ groups, the hyporeactive subgroup experienced a lower incidence of chronic rejection. The probability of donor antigen-specific hyporeactivity predicting a chronic rejection-free state is 100% for lung and 91% for heart recipients. We have identified peripheral blood allogeneic microchimerism for 77% (20/26) of lung and 36% (9/25) of heart recipients tested at 12-18 months posttransplant. Donor antigen- specific hyporeactivity correlates with a critical level of donor cells in lung recipients; the probability of high peripheral blood allogeneic microchimerism levels predicting a chronic rejection-free state in lung recipients is 100%. The results in heart recipients are not as clear with a short-, but not long-term, trend of higher chimerism levels correlating with the development of donor antigen-specific hyporeactivity. These results illustrate the usefulness of immune parameters to predict long-term graft outcome in an organ-specific manner.

Original languageEnglish (US)
Pages (from-to)306-309
Number of pages4
JournalJournal of Leukocyte Biology
Volume66
Issue number2
StatePublished - 1999
Externally publishedYes

Fingerprint

Chimerism
Allografts
Antigens
Lung
Steroids
Transplants
Incidence

Keywords

  • Chronic rejection
  • Donor antigen-specific hyporeactivity
  • Long-term graft outcome

ASJC Scopus subject areas

  • Cell Biology

Cite this

Reinsmoen, N. L., Jackson, A., Hertz, M., Savik, K., Kubo, S., Ormaza, S., ... McSherry, C. (1999). Peripheral blood allogeneic microchimerism in lung and cardiac allograft recipients. Journal of Leukocyte Biology, 66(2), 306-309.

Peripheral blood allogeneic microchimerism in lung and cardiac allograft recipients. / Reinsmoen, Nancy L.; Jackson, Annette; Hertz, Marshall; Savik, Kay; Kubo, Spencer; Ormaza, Sophia; Miller, Leslie; McSherry, Cynthia.

In: Journal of Leukocyte Biology, Vol. 66, No. 2, 1999, p. 306-309.

Research output: Contribution to journalArticle

Reinsmoen, NL, Jackson, A, Hertz, M, Savik, K, Kubo, S, Ormaza, S, Miller, L & McSherry, C 1999, 'Peripheral blood allogeneic microchimerism in lung and cardiac allograft recipients', Journal of Leukocyte Biology, vol. 66, no. 2, pp. 306-309.
Reinsmoen NL, Jackson A, Hertz M, Savik K, Kubo S, Ormaza S et al. Peripheral blood allogeneic microchimerism in lung and cardiac allograft recipients. Journal of Leukocyte Biology. 1999;66(2):306-309.
Reinsmoen, Nancy L. ; Jackson, Annette ; Hertz, Marshall ; Savik, Kay ; Kubo, Spencer ; Ormaza, Sophia ; Miller, Leslie ; McSherry, Cynthia. / Peripheral blood allogeneic microchimerism in lung and cardiac allograft recipients. In: Journal of Leukocyte Biology. 1999 ; Vol. 66, No. 2. pp. 306-309.
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