Peripheral and Central Mechanisms of Itch

Xintong Dong, Xinzhong Dong

Research output: Contribution to journalArticle

Abstract

Itch is a unique sensory experience that is encoded by genetically distinguishable neurons both in the peripheral nervous system (PNS) and central nervous system (CNS) to elicit a characteristic behavioral response (scratching). Itch interacts with the other sensory modalities at multiple locations, from its initiation in a particular dermatome to its transmission to the brain where it is finally perceived. In this review, we summarize the current understanding of the molecular and neural mechanisms of itch by starting in the periphery, where itch is initiated, and discussing the circuits involved in itch processing in the CNS. Dong and Dong summarize the current understanding of the molecular and neural mechanisms of itch. The authors first review the peripheral mediators that activate itch sensory neurons and then outline the circuits involved in itch processing in the CNS.

Original languageEnglish (US)
JournalNeuron
DOIs
StateAccepted/In press - Jan 1 2018

Keywords

  • cytokines
  • dorsal root ganglia
  • G protein-coupled receptors
  • itch
  • mast cells
  • neuroimmunology
  • pain
  • sensory neuron
  • spinal cord
  • TRP channels

ASJC Scopus subject areas

  • Neuroscience(all)

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