TY - JOUR
T1 - Peripartum complications associated with obsessive compulsive disorder exacerbation during pregnancy
AU - Holingue, Calliope
AU - Samuels, Jack
AU - Guglielmi, Valeria
AU - Ingram, Wendy
AU - Nestadt, Gerald
AU - Nestadt, Paul S.
N1 - Funding Information:
This research was supported, in part, by the National Institutes of Health grant R01 MH 50214 . CBH was supported by the NIMH Psychiatric Epidemiology Training Program ( 5T32MH014592-39 ; PI: Zandi, Peter). The funding agency had no role in the design and conduct of this study; in the collection, management, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript.
Publisher Copyright:
© 2021 Elsevier Inc.
PY - 2021/4
Y1 - 2021/4
N2 - Prior research has shown that onset or exacerbation of OCD is associated with menstruation, pregnancy, and the post-partum period. However, the underlying cause is unclear. The goal of this study was to assess whether pregnancy and birth complications were associated with OCD symptoms exacerbation, among women with established OCD. Two-hundred and five (n = 205) women with OCD retrospectively reported information on their physical and mental health during their first pregnancy. Over a third of the sample (34%) reported an exacerbation in their OCD symptoms. History of pregnancy and birth complications in the first pregnancy were similar between women who did and did not experience symptom exacerbation, with the exception of gestational diabetes, which was significantly more common among women who experienced exacerbation (7% vs 1%, p = 0.03). In a multivariable logistic regression model, gestational diabetes remained significantly associated with exacerbation of OCD symptoms (OR = 8.44 [95% CI 1.37–77.27]; p = 0.03), even after adjusting for maternal age, OCD severity and treatment, premenstrual OCD symptom increase, stress during pregnancy, and major depression or anxiety disorder diagnosis during pregnancy. We discuss potential explanations for this link. These findings should be treated as hypothesis-generating and need to be replicated in a larger, prospective study.
AB - Prior research has shown that onset or exacerbation of OCD is associated with menstruation, pregnancy, and the post-partum period. However, the underlying cause is unclear. The goal of this study was to assess whether pregnancy and birth complications were associated with OCD symptoms exacerbation, among women with established OCD. Two-hundred and five (n = 205) women with OCD retrospectively reported information on their physical and mental health during their first pregnancy. Over a third of the sample (34%) reported an exacerbation in their OCD symptoms. History of pregnancy and birth complications in the first pregnancy were similar between women who did and did not experience symptom exacerbation, with the exception of gestational diabetes, which was significantly more common among women who experienced exacerbation (7% vs 1%, p = 0.03). In a multivariable logistic regression model, gestational diabetes remained significantly associated with exacerbation of OCD symptoms (OR = 8.44 [95% CI 1.37–77.27]; p = 0.03), even after adjusting for maternal age, OCD severity and treatment, premenstrual OCD symptom increase, stress during pregnancy, and major depression or anxiety disorder diagnosis during pregnancy. We discuss potential explanations for this link. These findings should be treated as hypothesis-generating and need to be replicated in a larger, prospective study.
KW - Exacerbation
KW - Hormonal
KW - Obsessive-compulsive disorder
KW - Pregnancy
KW - Reproductive
UR - http://www.scopus.com/inward/record.url?scp=85103311944&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85103311944&partnerID=8YFLogxK
U2 - 10.1016/j.jocrd.2021.100641
DO - 10.1016/j.jocrd.2021.100641
M3 - Article
C2 - 33968604
AN - SCOPUS:85103311944
SN - 2211-3649
VL - 29
JO - Journal of Obsessive-Compulsive and Related Disorders
JF - Journal of Obsessive-Compulsive and Related Disorders
M1 - 100641
ER -