Perioperatively Inhaled Hydrogen Gas Diminishes Neurologic Injury Following Experimental Circulatory Arrest in Swine

Alexis R. Cole; Dorothy A. Perry; Ali Raza; Arthur P. Nedder; Elizabeth Pollack; William L. Regan; Sarah J. van den Bosch; Brian D. Polizzotti; Edward Yang; Daniel Davila; Onur Afacan; Simon K. Warfield; Yangming Ou; Brenda Sefton; Allen D. Everett; Jeffrey J. Neil; Hart G.W. Lidov; John E. Mayer; John N. Kheir

doi:10.1016/j.jacbts.2018.11.006

Perioperatively Inhaled Hydrogen Gas Diminishes Neurologic Injury Following Experimental Circulatory Arrest in Swine

Alexis R. Cole, Dorothy A. Perry, Ali Raza, Arthur P. Nedder, Elizabeth Pollack, William L. Regan, Sarah J. van den Bosch, Brian D. Polizzotti, Edward Yang, Daniel Davila, Onur Afacan, Simon K. Warfield, Yangming Ou, Brenda Sefton, Allen D. Everett, Jeffrey J. Neil, Hart G.W. Lidov, John E. Mayer, John N. Kheir

School of Medicine

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

This study used a swine model of mildly hypothermic prolonged circulatory arrest and found that the addition of 2.4% inhaled hydrogen gas to inspiratory gases during and after the ischemic insult significantly decreased neurologic and renal injury compared with controls. With proper precautions, inhalational hydrogen may be administered safely through conventional ventilators and may represent a complementary therapy that can be easily incorporated into current workflows. In the future, inhaled hydrogen may diminish the sequelae of ischemia that occurs in congenital heart surgery, cardiac arrest, extracorporeal life-support events, acute myocardial infarction, stroke, and organ transplantation.

Original language	English (US)
Pages (from-to)	176-187
Number of pages	12
Journal	JACC: Basic to Translational Science
Volume	4
Issue number	2
DOIs	https://doi.org/10.1016/j.jacbts.2018.11.006
State	Published - Apr 2019

Keywords

circulatory arrest
hydrogen gas
ischemia-reperfusion injury
neuroprotection

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.jacbts.2018.11.006

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Cole, A. R., Perry, D. A., Raza, A., Nedder, A. P., Pollack, E., Regan, W. L., van den Bosch, S. J., Polizzotti, B. D., Yang, E., Davila, D., Afacan, O., Warfield, S. K., Ou, Y., Sefton, B., Everett, A. D., Neil, J. J., Lidov, H. G. W., Mayer, J. E., & Kheir, J. N. (2019). Perioperatively Inhaled Hydrogen Gas Diminishes Neurologic Injury Following Experimental Circulatory Arrest in Swine. JACC: Basic to Translational Science, 4(2), 176-187. https://doi.org/10.1016/j.jacbts.2018.11.006

Cole, AR, Perry, DA, Raza, A, Nedder, AP, Pollack, E, Regan, WL, van den Bosch, SJ, Polizzotti, BD, Yang, E, Davila, D, Afacan, O, Warfield, SK, Ou, Y, Sefton, B, Everett, AD, Neil, JJ, Lidov, HGW, Mayer, JE & Kheir, JN 2019, 'Perioperatively Inhaled Hydrogen Gas Diminishes Neurologic Injury Following Experimental Circulatory Arrest in Swine', JACC: Basic to Translational Science, vol. 4, no. 2, pp. 176-187. https://doi.org/10.1016/j.jacbts.2018.11.006

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title = "Perioperatively Inhaled Hydrogen Gas Diminishes Neurologic Injury Following Experimental Circulatory Arrest in Swine",

abstract = "This study used a swine model of mildly hypothermic prolonged circulatory arrest and found that the addition of 2.4% inhaled hydrogen gas to inspiratory gases during and after the ischemic insult significantly decreased neurologic and renal injury compared with controls. With proper precautions, inhalational hydrogen may be administered safely through conventional ventilators and may represent a complementary therapy that can be easily incorporated into current workflows. In the future, inhaled hydrogen may diminish the sequelae of ischemia that occurs in congenital heart surgery, cardiac arrest, extracorporeal life-support events, acute myocardial infarction, stroke, and organ transplantation.",

keywords = "circulatory arrest, hydrogen gas, ischemia-reperfusion injury, neuroprotection",

author = "Cole, {Alexis R.} and Perry, {Dorothy A.} and Ali Raza and Nedder, {Arthur P.} and Elizabeth Pollack and Regan, {William L.} and {van den Bosch}, {Sarah J.} and Polizzotti, {Brian D.} and Edward Yang and Daniel Davila and Onur Afacan and Warfield, {Simon K.} and Yangming Ou and Brenda Sefton and Everett, {Allen D.} and Neil, {Jeffrey J.} and Lidov, {Hart G.W.} and Mayer, {John E.} and Kheir, {John N.}",

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doi = "10.1016/j.jacbts.2018.11.006",

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AU - Cole, Alexis R.

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AU - Raza, Ali

AU - Nedder, Arthur P.

AU - Pollack, Elizabeth

AU - Regan, William L.

AU - van den Bosch, Sarah J.

AU - Polizzotti, Brian D.

AU - Yang, Edward

AU - Davila, Daniel

AU - Afacan, Onur

AU - Warfield, Simon K.

AU - Ou, Yangming

AU - Sefton, Brenda

AU - Everett, Allen D.

AU - Neil, Jeffrey J.

AU - Lidov, Hart G.W.

AU - Mayer, John E.

AU - Kheir, John N.

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AB - This study used a swine model of mildly hypothermic prolonged circulatory arrest and found that the addition of 2.4% inhaled hydrogen gas to inspiratory gases during and after the ischemic insult significantly decreased neurologic and renal injury compared with controls. With proper precautions, inhalational hydrogen may be administered safely through conventional ventilators and may represent a complementary therapy that can be easily incorporated into current workflows. In the future, inhaled hydrogen may diminish the sequelae of ischemia that occurs in congenital heart surgery, cardiac arrest, extracorporeal life-support events, acute myocardial infarction, stroke, and organ transplantation.

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KW - hydrogen gas

KW - ischemia-reperfusion injury

KW - neuroprotection

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Perioperatively Inhaled Hydrogen Gas Diminishes Neurologic Injury Following Experimental Circulatory Arrest in Swine

Abstract

Keywords

ASJC Scopus subject areas

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