Perioperative myocardial ischemic episodes are related to hematocrit level in patients undergoing radical prostatectomy

C. W. Hogue, L. T. Goodnough, T. G. Monk

Research output: Contribution to journalArticle

Abstract

BACKGROUND: The anemia associated with perioperative blood conservation has raised concerns regarding the safety of these strategies in patients with ischemic cardiovascular disease. Therefore the relationship between hematocrit level and myocardial ischemic episodes in a group of elderly patients undergoing elective noncardiac surgery was studied. STUDY DESIGN AND METHODS: One hundred ninety patients undergoing radical prostatectomy were randomly assigned to one of three blood conservation groups: preoperative autologous blood donation, acute normovolemic hemodilution, and preoperative erythropoietin therapy with acute normovolemic hemodilution. Patients underwent ambulatory electrocardiography monitoring to evaluate for myocardial ischemia at randomization (baseline), 7 days preoperatively, throughout surgery, and for 24 hours after surgery. RESULTS: Myocardial ischemic episodes occurred in 61 (34%) of 181 evaluable patients. Patients with hematocrit levels

Original languageEnglish (US)
Pages (from-to)924-931
Number of pages8
JournalTransfusion
Volume38
Issue number10
StatePublished - Oct 1998
Externally publishedYes

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Prostatectomy
Hematocrit
Hemodilution
Ambulatory Electrocardiography
Blood Group Antigens
Random Allocation
Erythropoietin
Blood Donors
Myocardial Ischemia
Anemia
Cardiovascular Diseases
Safety

ASJC Scopus subject areas

  • Hematology
  • Immunology

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Perioperative myocardial ischemic episodes are related to hematocrit level in patients undergoing radical prostatectomy. / Hogue, C. W.; Goodnough, L. T.; Monk, T. G.

In: Transfusion, Vol. 38, No. 10, 10.1998, p. 924-931.

Research output: Contribution to journalArticle

Hogue, C. W. ; Goodnough, L. T. ; Monk, T. G. / Perioperative myocardial ischemic episodes are related to hematocrit level in patients undergoing radical prostatectomy. In: Transfusion. 1998 ; Vol. 38, No. 10. pp. 924-931.
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