Perioperative anesthetic and analgesic management of newborn bladder exstrophy repair

Sabine Kost-Byerly, Eric V. Jackson, Myron Yaster, Lori J. Kozlowski, Ranjiv I. Mathews, John P. Gearhart

Research output: Contribution to journalArticlepeer-review


Objective: Reconstruction of bladder exstrophy in newborn infants requires immobilization, sedation and pain management to prevent distracting forces from compromising the repair. We present a 6-year review of our experience. Subjects and methods: We reviewed the perioperative management of newborn infants undergoing reconstruction between November 1999 and October 2006. Data are presented as means ± SD. Results: Twenty-three newborn infants underwent surgery under a combined epidural and general anesthetic technique. Tunneled caudal epidural catheters were inserted in all patients and intermittently injected with 0.25% bupivacaine with 1:200,000 epinephrine. Postoperatively, a continuous infusion of 0.1% lidocaine, 0.8-1 mg/kg/h was administered for 15 ± 8 (range 4-30) days. Children were sedated with diazepam for 20 ± 13 (range 2-40) days. Central venous catheters were maintained for 20 ± 9 (range 1-34) days for fluids, drug administration and blood sampling. No patient experienced bladder prolapse or wound dehiscence. Conclusion: Perioperative management with tunneled epidural and central venous catheters in newborn infants with bladder exstrophy facilitates immobilization, analgesia and sedation, resulting in an excellent cosmetic repair with no case of bladder prolapse or wound dehiscence.

Original languageEnglish (US)
Pages (from-to)280-285
Number of pages6
JournalJournal of pediatric urology
Issue number4
StatePublished - Aug 1 2008


  • Analgesia, epidural
  • Anesthesia, caudal
  • Bladder exstrophy
  • Infant, newborn

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Urology


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