Periocular squamous cell carcinoma

Vanessa Limawararut, Igal Leibovitch, Tim Sullivan, Dinesh Selva

Research output: Contribution to journalArticle

Abstract

Squamous cell carcinoma (SCC) is the second most common eyelid malignancy and its incidence is increasing. Because of its variable clinical presentation, SCC may be difficult for even the experienced clinician to diagnose. Hence, all suspicious lesions warrant biopsy. As SCC behaviour may range widely in aggression, management should be individualized based on tumour (e.g. size, location, grade, histological subtype, previous recurrence, perineural invasion) and patient factors (e.g. age, health). Treatment of eyelid SCC should include margin control whenever possible for the highest cure rate in this high-risk area. Immediate histological monitoring of surgical margins with frozen sections or Mohs'micrographic surgery also allows for smaller margins of excision in an area where tissue conservation is important. Other special considerations in the periocular area include maintaining a high level of suspicion for perineural invasion as this may be associated with a poorer prognosis.

Original languageEnglish (US)
Pages (from-to)174-185
Number of pages12
JournalClinical and Experimental Ophthalmology
Volume35
Issue number2
DOIs
StatePublished - Mar 1 2007

Keywords

  • Cutaneous malignancy
  • Eyelid squamous cell carcinoma
  • Non-melanoma skin cancer
  • Periorbital skin cancer
  • Periorbital squamous cell carcinoma

ASJC Scopus subject areas

  • Ophthalmology

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  • Cite this

    Limawararut, V., Leibovitch, I., Sullivan, T., & Selva, D. (2007). Periocular squamous cell carcinoma. Clinical and Experimental Ophthalmology, 35(2), 174-185. https://doi.org/10.1111/j.1442-9071.2006.01411.x