TY - JOUR
T1 - Perinatal outcome in women with recurrent preeclampsia compared with women who develop preeclampsia as nulliparas
AU - National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units
AU - Hnat, Michael D.
AU - Sibai, Baha M.
AU - Caritis, Steve
AU - Hauth, John
AU - Lindheimer, Marshall D.
AU - MacPherson, Cora
AU - Van Dorsten, J. Peter
AU - Landon, Mark
AU - Miodovnik, Menachem
AU - Paul, Richard
AU - Meis, Paul
AU - Thurnau, Gary
AU - Dombrowski, Mitchell
AU - Harger, J.
AU - Controneo, M.
AU - Kamon, T.
AU - Mercer, B.
AU - Ramsey, R.
AU - Rabello, Y.
AU - McCart, D.
AU - Mueller, E.
AU - Goldenberg, R.
AU - Cooper, R.
AU - Norman, G.
AU - Millinder, A.
AU - Christmas, J.
AU - McCoy, S.
AU - Elder, S.
AU - Elder, N.
AU - Carter, B.
AU - Schneider, V.
AU - Meier, A.
AU - Minton, V.
AU - Swain, M.
AU - Ernest, J. M.
AU - Moawad, A.
AU - Jones, P.
AU - Iams, J.
AU - Meadows, S.
AU - Brenner, S.
AU - Collins, B.
AU - Newman, R.
AU - Carter, S.
AU - Romero, R.
AU - Sabo, V.
AU - Godfrey, S.
AU - Rosen, M.
AU - Chao, R.
AU - Witter, R.
AU - Rocco, L.
N1 - Funding Information:
Supported by grants HD19897, HD21410, HD21414, HD21434, HD27860, HD27861, HD27869, HD27883, HD27889, HD27905, HD27915, and HD27917 from the National Institute for Child Health and Human Development.
PY - 2002/3
Y1 - 2002/3
N2 - OBJECTIVE: To compare the rates and perinatal outcome in women who experienced preeclampsia in a previous pregnancy to those in women who developed preeclampsia as nulliparas. STUDY DESIGN: This is a secondary analysis of data from 2 separate multi-center trials of aspirin for prevention of preeclampsia. Women who had preeclampsia in a previous pregnancy (n = 598) were compared with nulliparous women (n = 2934). Outcome variables were rates of preeclampsia, preterm delivery at <37 and <35 weeks of gestation, small-for-gestational-age infant, abruptio placentae, and perinatal death. Data were compared by using chi-square analysis and Wilcoxon rank sum test. RESULTS: The rates of preeclampsia and of severe preeclampsia were significantly higher in the previous preeclamptic group as compared to the nulliparous group (17.9% vs 5.3%, P <.0001, and 7.5% vs. 2.4%, P <.0001, respectively). Women who had recurrent preeclampsia experienced more preterm deliveries before 37 and 35 weeks of gestation than nulliparous women who developed preeclampsia. In addition, among women who developed severe preeclampsia, those with recurrent preeclampsia had higher rates of preterm delivery both before 37 weeks (67% vs 33%, P =.0004) and before 35 weeks of gestation (36% vs 19%, P=.041), and higher rates of abruptio placentae (6.7% vs 1.5%) and fetal death (6.7% vs 1.4%) than did nulliparous women. CONCLUSION: Compared to nulliparous women, women with preeclampsia in a previous pregnancy had significantly higher rates of preeclampsia and adverse perinatal outcomes associated with preterm delivery as a result of preeclampsia.
AB - OBJECTIVE: To compare the rates and perinatal outcome in women who experienced preeclampsia in a previous pregnancy to those in women who developed preeclampsia as nulliparas. STUDY DESIGN: This is a secondary analysis of data from 2 separate multi-center trials of aspirin for prevention of preeclampsia. Women who had preeclampsia in a previous pregnancy (n = 598) were compared with nulliparous women (n = 2934). Outcome variables were rates of preeclampsia, preterm delivery at <37 and <35 weeks of gestation, small-for-gestational-age infant, abruptio placentae, and perinatal death. Data were compared by using chi-square analysis and Wilcoxon rank sum test. RESULTS: The rates of preeclampsia and of severe preeclampsia were significantly higher in the previous preeclamptic group as compared to the nulliparous group (17.9% vs 5.3%, P <.0001, and 7.5% vs. 2.4%, P <.0001, respectively). Women who had recurrent preeclampsia experienced more preterm deliveries before 37 and 35 weeks of gestation than nulliparous women who developed preeclampsia. In addition, among women who developed severe preeclampsia, those with recurrent preeclampsia had higher rates of preterm delivery both before 37 weeks (67% vs 33%, P =.0004) and before 35 weeks of gestation (36% vs 19%, P=.041), and higher rates of abruptio placentae (6.7% vs 1.5%) and fetal death (6.7% vs 1.4%) than did nulliparous women. CONCLUSION: Compared to nulliparous women, women with preeclampsia in a previous pregnancy had significantly higher rates of preeclampsia and adverse perinatal outcomes associated with preterm delivery as a result of preeclampsia.
KW - Perinatal outcome
KW - Preeclampsia
KW - Recurrence
UR - http://www.scopus.com/inward/record.url?scp=0036126694&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036126694&partnerID=8YFLogxK
U2 - 10.1067/mob.2002.120280
DO - 10.1067/mob.2002.120280
M3 - Article
C2 - 11904601
AN - SCOPUS:0036126694
VL - 186
SP - 422
EP - 426
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
SN - 0002-9378
IS - 3
ER -